| Identification | Back Directory | [Name]
(4-HYDROXYMETHYL-BENZYL)-CARBAMIC ACID TERT-BUTYL ESTER | [CAS]
123986-64-1 | [Synonyms]
4-(BOC-AMINOMETHYL-PHENYL)-METHANOL
N-Boc-4-(aminomethyl)benzyl Alcohol
4-(N-Boc-aMinoMethyl)benzyl alcohol
tert-BUTYL-4-(HYDROXYMETHYL)BENZYLCARBAMATE
4-(Aminomethyl)benzyl alcohol, N-BOC protected
4-(Aminomethyl)benzylalcohol,N-BOCprotected97%
4-(tert-Butoxycarbonylaminomethyl)benzyl alcohol
tert-Butyl [4-(hydroxymethyl)benzyl]carbamate 97%
4-(Aminomethyl)benzyl alcohol, N-BOC protected 97%
4-(N-TERT-BUTOXYCARBONYLAMINOMETHYL)BENZYL ALCOHOL
4-(N-tert-Butoxycarbonylaminomethyl)benzyl alcohol 97%
(4-hydroxymethyl-benzyl)-carbamic acid ter-butyl ester
tert-butyl N-[[4-(hydroxymethyl)phenyl]methyl]carbamate
(4-HYDROXYMETHYL-BENZYL)-CARBAMIC ACID TERT-BUTYL ESTER
4-[N-(tert-butoxycarbonyl)aminomethyl]-1-phenylmethanol
Carbamic acid, N-[[4-(hydroxymethyl)phenyl]methyl]-, 1,1-dimethylethyl ester
tert-Butyl [4-(hydroxymethyl)benzyl]carbamate, 4-(Hydroxymethyl)benzylamine, N-BOC protected | [Molecular Formula]
C13H19NO3 | [MDL Number]
MFCD06411553 | [MOL File]
123986-64-1.mol | [Molecular Weight]
237.29 |
| Chemical Properties | Back Directory | [Melting point ]
98 °C | [Boiling point ]
397.2±30.0 °C(Predicted) | [density ]
1.106±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [form ]
solid | [pka]
12.19±0.46(Predicted) | [color ]
White |
| Hazard Information | Back Directory | [Synthesis]
GENERAL STEPS: A mixture of 4-(aminomethyl)benzenemethanol (1 g, 7.29 mmol) and di-tert-butyl dicarbonate (1.59 g, 7.29 mmol) in dichloromethane (30 mL) was reacted at room temperature with stirring overnight. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography with the eluent being a solvent mixture of dichloromethane and ethyl acetate (1:1, v/v) to afford tert-butyl 4-(hydroxymethyl)benzylcarbamate (0.8 g, 2.28 mmol, 31% yield) as a white solid. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 7.37 (s, 1H), 7.22 (dd, J = 27.8, 8.0 Hz, 4H), 5.13 (t, J = 5.7 Hz, 1H), 4.46 (d, J = 5.7 Hz, 2H), 4.10 (d, J = 6.1 Hz, 2H), 1.36 (s, 9H ). | [References]
[1] Patent: WO2006/12135, 2006, A1. Location in patent: Page/Page column 49-51
[2] Patent: US2006/293379, 2006, A1. Location in patent: Page/Page column 63
[3] Angewandte Chemie - International Edition, 2012, vol. 51, # 4, p. 941 - 944
[4] Chemical Communications, 2010, vol. 46, # 7, p. 1073 - 1075
[5] Journal of Medicinal Chemistry, 2009, vol. 52, # 1, p. 33 - 47 |
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