Back to ChemicalBook Home--->CAS DataBase List--->124-87-8

124-87-8

124-87-8 Structure

124-87-8 Structure
IdentificationBack Directory
[Name]

PICROTOXIN
[CAS]

124-87-8
[Synonyms]

1:1)[qr]
COCCULIN
Cocculus
COCCULINE
fishberry
PICROTOXIN
picrotoxine
indianberry
cocculin[qr]
picrotox[qr]
orientalberry
fishberry[qr]
ai3-17689[qr]
coquesdulevant
PICROTOXIN(RG)
Picrotoxin,98%
Picrotoxin USP
PICROTOXIN pure
picrotoxine[qr]
indianberry[qr]
picrotoxinum[qr]
caswellno663a[qr]
PicrotoxinCocculin
Picrotoxin (natural)
coquesdulevant(french)[qr]
COCCULIN(SEE PICROTOXIN)(RG)
PICROTOXIN, ANAMIRTA COCCULIN
epapesticidechemicalcode002301[qr]
1:1mixtureofpicrotoxininandpicrotin
picrotoxinin,compd.withpicrotin(1:1)
picrotin,compd.withpicrotoxinin(1:1)
Picrotoxin (Picrotoxinin + Picrotin)
picrotin,compoundwithpicrotoxinin(1:1)[qr]
Molecular complex (1:1) of picrotin and picrotoxinin
Picrotoxin (1:1 Mixture of Picrotoxinin and Picrotin)
3beta,6beta,6abeta,8as*,8bbeta,9s*))-,compdwith(1ar-(1aalpha,2abeta,3beta,6b
)-3,6-methano-8h-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3h)-dione(
ahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-,(1ar-(1aalpha,2abeta,
3,6-methano-8h-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3h)-dione,hex
eta,6abeta,8as*,8bbeta,9r*))-hexahydro-2a-hydroxy-8b-methyl-9-(1-methylethenyl
[EINECS(EC#)]

204-716-6
[Molecular Formula]

C30H34O13
[MDL Number]

MFCD00074824
[Molecular Weight]

602.58
[MOL File]

124-87-8.mol
Chemical PropertiesBack Directory
[Description]

Picrotoxin, also known as cocculin, appears as white to light beige crystalline material. It is isolated from Cocculus indicus (Fructus cocculi), fishberries, or Indian berries. Picrotoxin is a colourless, flexible, shining, prismatic crystals, or a micro-crystalline powder. It is odourless, has a very bitter taste, and is permanent in the air. Picrotoxin is soluble in hot water, readily soluble in strong ammonia water, and in aqueous solutions of sodium hydroxide, soluble in dilute acids, and alkalis as well as in glacial acetic acid, sparingly soluble in chloroform and very slightly soluble in cold water and alcohol. Picrotoxin is stable under normal temperatures and pressures and decompose when exposed to light. Picrotoxin is incompatible with strong oxidising agents, strong acids, strong bases, light.
[Appearance]

Picrotoxin is an odorless crystalline solid with a very bitter taste.
[Appearance]

white to off-white powder or crystals
[Melting point ]

203 °C(lit.)
[alpha ]

D16 -29.3° (c = 4 in abs ethanol)
[density ]

1,28 g/cm3
[storage temp. ]

Store at RT
[solubility ]

ethanol: 50 mg/mL, clear to slightly hazy
[form ]

powder
[color ]

white to light yellow
[Merck ]

14,7415
Hazard InformationBack Directory
[Chemical Properties]

white to off-white powder or crystals
[General Description]

A poisonous berry, the dried fruit of Anamirta PICROTOXIN L. Contains several substances including about one percent picrotoxin. Pure picrotoxin occurs as shiny leaflets with an intensely bitter taste or as a microcrystalline powder. Very poisonous!. Used in medicine as a central nervous system stimulant and antidote for barbiturate poisoning. Not currently regarded as a useful therapeutic agent.
[Reactivity Profile]

PICROTOXIN contains picrotoxin, a molecular compound of picrotoxinin and picrotin. May react with strong oxidizing agents and with strong reducing agents.
[Health Hazard]

Highly toxic and a dose of 20 mg may produce symptoms of severe poisoning. A human lethal dose of 1.5 mg/kg has been reported. It is an alkaloid convulsant poison.
[Fire Hazard]

When heated to decomposition PICROTOXIN emits acrid smoke and fumes. Avoid decomposing heat.
[Biological Activity]

GABA A receptor antagonist; potent CNS stimulant.
[Potential Exposure]

An alkaloid poison and convulsant. Used in medicine as a CNS stimulant and antidote for barbiturate poisoning. Reportedly, this material is not currently regarded as a useful therapeutic agent since it is not a selective respiratory stimulant.
[First aid]

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit. Keep victim quiet and maintain normal body temperature. Effects may be delayed, keep victim under observation.
[Shipping]

UN3462 Toxins, extracted from living sources, solid, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN3172 Toxins, extracted from living sources, (solid or liquid) Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
[Incompatibilities]

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.
[Waste Disposal]

It is inappropriate and possibly dangerous to the environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, doublebagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.
Safety DataBack Directory
[Hazard Codes ]

T+,T,N
[Risk Statements ]

28-52/53
[Safety Statements ]

28-36/37/39-45-61
[RIDADR ]

UN 3462 6.1/PG 2
[WGK Germany ]

3
[RTECS ]

TJ9100000
[F ]

8-10
[Hazard Note ]

Very Toxic
[HazardClass ]

6.1(a)
[PackingGroup ]

I
[HS Code ]

29322985
[Safety Profile]

A human poison by ingestion. Poison experimentally by most routes. Human systemic effects by ingestion: somnolence, gastrointestinal effects. An alkaloid convulsant poison. When heated to decomposition it emits acrid smoke and irritating fumes.
Spectrum DetailBack Directory
[Spectrum Detail]

PICROTOXIN(124-87-8)IR2
PICROTOXIN(124-87-8)IR1
PICROTOXIN(124-87-8)Raman
124-87-8 suppliers list
Company Name: Hubei xin bonus chemical co. LTD
Tel: 13657299721
Fax:
Website: www.chemicalbook.com/ShowSupplierProductsList1549548/0.htm
Company Name: Hubei Jusheng Technology Co.,Ltd.
Tel: 86-188-71490254
Fax:
Website: www.chemicalbook.com/ShowSupplierProductsList31316/0.htm
Company Name: 3B Pharmachem (Wuhan) International Co.,Ltd.  
Tel:86-21-50328103 * 801、802、803、804 Mobile:18930552037
Fax:86-21-50328109
Website:
Company Name: TCI (Shanghai) Development Co., Ltd.  
Tel:021-67121386 / 800-988-0390
Fax:021-67121385
Website:www.tcichemicals.com
Company Name: Chemsky(shanghai)International Co.,Ltd.  
Tel:021-50135380
Fax:
Website:www.shchemsky.com
Company Name: Sinopharm Chemical Reagent Co,Ltd.  
Tel:86-21-63210123
Fax:86-21-63290778 86-21-63218885
Website:www.reagent.com.cn
Company Name: Chengdu Biopurify Phytochemicals Ltd.  
Tel:86-28-82633397
Fax:+86-28-82633165
Website:www.biopurify.cn
Company Name: Chengdu Climax Biotech Co., Ltd.  
Tel:028-83311324 QQ:1278112614
Fax:028-83311324
Website:www.climax-biotech.com
Company Name: Thermo Fisher Scientific  
Tel:800-810-5118
Fax:+86-10-84193589
Website:www.thermo.com.cn
Company Name: Beijing HuaMeiHuLiBiological Chemical   
Tel:010-56205725;010-86181995
Fax:010-65763397
Website:www.huabeibiochem.com
Company Name: Shanghai Tauto Biotech Co., Ltd  
Tel:0086-21-51320588
Fax:0086-21-51320502
Website:www.tautobiotech.com
Company Name: Sichuan Wei Keqi Biological Technology Co., Ltd.  
Tel:028-81700200 QQ:2851167785
Fax:028-81705658
Website:www.weikeqi-biotech.com
Company Name: Chengdu HuaXia Chemical Reagent Co. Ltd  
Tel:400-1166-196 18981987031
Fax:028-84555506 QQ:800101999
Website:www.hx-r.com
Company Name: HangZhou YuHao Chemical Technology Co., Ltd.  
Tel:0571-82693216
Fax:0571-82880190
Website:www.yuhaochemical.com
Company Name: Sigma-Aldrich  
Tel:021-61415566 800-819-3336(Tel) 400-620-3333(Mobile)
Fax:
Website:www.sigmaaldrich.com
Company Name: Shandong XiYa Chemical Industry Co., Ltd  
Tel:4008-626-111
Fax:0539-6365991
Website:www.xiyashiji.com
Company Name: Guangdong wengjiang Chemical Reagent Co., Ltd.  
Tel:0751-2886750/15914351330
Fax:0751-2886756 QQ:3001264886
Website:www.wj-chem.com
Company Name: Shandong Ono Chemical Co., Ltd.  
Tel:0539-6362799(To 20)
Fax:0539-6362799(To 20)
Website:www.onochem.com
Tags:124-87-8 Related Product Information
21490-63-1 637-65-0 2110-78-3 112-73-2 3301-94-8 599-04-2 80-55-7 4630-80-2