| Identification | Back Directory | [Name]
9-AMINO-1,2,3,4-TETRAHYDRO-ACRIDIN-1-OL | [CAS]
124027-47-0 | [Synonyms]
PD-131620
1-Hydroxytacrine
9-AMINO-1,2,3,4-TETRAHYDRO-ACRIDIN-1-OL | [Molecular Formula]
C13H14N2O | [MDL Number]
MFCD00600017 | [MOL File]
124027-47-0.mol | [Molecular Weight]
214.26 |
| Chemical Properties | Back Directory | [Melting point ]
245℃ | [Boiling point ]
450.3±45.0 °C(Predicted) | [density ]
1.315±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [pka]
13.47±0.20(Predicted) |
| Hazard Information | Back Directory | [Uses]
Velnacrine (HP 029 free base) is an inhibitor for acetylcholinesterase (AChE), with an IC50 of 3.27 μM. Velnacrine reverses the Scopolamine (HY-N0296)-induced amnesia in rat models, and exhibits acute toxicity with LD50 of 65 mg/kg[1]. | [Definition]
ChEBI: 9-amino-1,2,3,4-tetrahydroacridin-1-ol is a member of acridines. | [IC 50]
AChE: 3.27 μM (IC50) | [References]
[1] Tabarrini O, et al., Velnacrine thiaanalogues as potential agents for treating Alzheimer's disease. Bioorg Med Chem. 2001 Nov;9(11):2921-8. DOI:10.1016/s0968-0896(01)00171-7 |
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