1240489-67-1

Directory

1240489-67-1 Structure

Identification	Back Directory
[Name] N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-[2-(3-pyridinyl)ethynyl]benzamide
[CAS] 1240489-67-1
[Synonyms] N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-[2-(3-pyridinyl)ethynyl]benzamide
[Molecular Formula] C29H29F3N4O
[MOL File] 1240489-67-1.mol
[Molecular Weight] 506.56

Chemical Properties	Back Directory
[Boiling point ] 565.9±50.0 °C(Predicted)
[density ] 1.29±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
[pka] 12.99±0.70(Predicted)

Hazard Information	Back Directory
[Uses] XMD15-44 is a RET kinase inhibitor.XMD15-44 has a growth-inhibitory effect on RET/C634R and RET/M918T transformed RAT1 cells, with IC50 values of 11.5 nM and 8.3 nM, respectively. XMD15-44 can inhibit RET kinase and signaling in human thyroid cancer cell lines carrying oncogenic RET alleles, reducing cell proliferation[1].
[References] [1] Moccia M, et al. Identification of Novel Small Molecule Inhibitors of Oncogenic RET Kinase. PLoS One. 2015 Jun 5;10(6):e0128364. DOI:10.1371/journal.pone.0128364

1240489-67-1 suppliers list

Tags:1240489-67-1 Related Product Information

HomePage | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Privacy | Terms | About Us
All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.

Login