| Identification | Back Directory | [Name]
VZRIHFZJVIOJBE-UHFFFAOYSA-N | [CAS]
1240494-13-6 | [Synonyms]
VZRIHFZJVIOJBE-UHFFFAOYSA-N | [Molecular Formula]
C19H16BFN2O3S | [MDL Number]
MFCD28963933 | [MOL File]
1240494-13-6.mol | [Molecular Weight]
382.22 |
| Hazard Information | Back Directory | [Description]
SX-517 is a potent noncompetitive boronic acid CXCR1/2 antagonist. SX-517 inhibited CXCL1-induced Ca(2+) flux (IC50 = 38 nM) in human PMNs but had no effect on the Ca(2+) flux induced by C5a, fMLF, or PAF. SX-517 is the first reported boronic acid chemokine antagonist and represents a novel pharmacophore for CXCR1/2 antagonism. |
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