| | Hazard Information | Back Directory |  | [Description] 
 DAC 5945 is a more potent muscarinic antagonist in the airways than in the heart, demonstrating M3/M2 selectivity in vivo.
 |  | [Uses] 
 DAC 5945 is a potent muscarinic antagonist in the airways than in the heart, with pKi values of 8.3 and 7.52 for M1 and M2, respectively[1][2].
 |  | [References] 
 [1] R E Howell, et al. Airway smooth muscle selectivity of the muscarinic antagonist DAC 5945 in vivo. Eur J Pharmacol. 1991 Apr 24;196(3):323-6. DOI:10.1016/0014-2999(91)90447-x
 [2] H N Doods, et al. Characterization of muscarinic receptors in guinea-pig uterus. Eur J Pharmacol. 1993 Dec 7;250(2):223-30. DOI:10.1016/0014-2999(93)90385-u
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