| Identification | Back Directory | [Name]
(1S,2R,3R)-Aprepitant | [CAS]
1242175-34-3 | [Synonyms]
Aprepitant Impurity 7
(2R,3R,1’S)-Aprepitant
Aprepitant iMpurity 31
Aprepitant (S,R,R)-Isomer
Aprepitant Impurity 4(S,R,R-Isomer)
Aprepitant impurity 8/(1S,2R,3R)-Aprepitant
5-([(2R,3R)-2-((S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy)-3-(4-fluoro phenyl)morpholino]methyl)-1H-1,2,4-triazol-3(2H)-one
5-[[(2R,3R)-2-[(1S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one
3H-1,2,4-Triazol-3-one, 5-[[(2R,3R)-2-[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro- | [Molecular Formula]
C23H21F7N4O3 | [MOL File]
1242175-34-3.mol | [Molecular Weight]
534.43 |
| Hazard Information | Back Directory | [Uses]
(2R,3R,1’S)-Aprepitant is an impurity of Aprepitant (A729800); a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic. |
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