| Identification | Back Directory | [Name]
BRPF1B TRIM24-IN-34 | [CAS]
1242907-48-7 | [Synonyms]
BRPF1B TRIM24-IN-34
Benzenesulfonamide, N-[2,3-dihydro-6-(4-methoxyphenoxy)-1,3-dimethyl-2-oxo-1H-benzimidazol-5-yl]-3,4-dimethoxy- | [Molecular Formula]
C24H25N3O7S | [MDL Number]
MFCD27141560 | [MOL File]
1242907-48-7.mol | [Molecular Weight]
499.54 |
| Hazard Information | Back Directory | [Uses]
BRPF1B/TRIM24-IN-1 (compound 34) is a potent TRIM24/BRPF1/BRPF2 inhibitor, with IC50 values of 0.43, 0.34, 1.75 μM, respectively. BRPF1B/TRIM24-IN-1 binds the TRIM24 bromodomain with a KD of 222 nM and has a KD for the BRPF1 bromodomain of 137 nM and for BRD1 of 1130 nM[1]. | [IC 50]
BRPF1: 0.34 μM (IC50); BRPF2: 1.75 μM (IC50) | [References]
[1] Bennett J, et al. Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF. J Med Chem. 2016 Feb 25;59(4):1642-7. DOI:10.1021/acs.jmedchem.5b00458 |
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