| Identification | Back Directory | [Name]
12:0(2S-OH) Ceramide | [CAS]
1246298-45-2 | [Synonyms]
12:0(2S-OH) Ceramide
Dodecanamide, 2-hydroxy-N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-, (2S)- | [Molecular Formula]
C30H59NO4 | [MDL Number]
MFCD22416670 | [MOL File]
1246298-45-2.mol | [Molecular Weight]
497.79 |
| Chemical Properties | Back Directory | [Boiling point ]
665.9±55.0 °C(Predicted) | [density ]
0.962±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [form ]
powder | [pka]
13.26±0.20(Predicted) |
| Hazard Information | Back Directory | [Biological Activity]
Hydroxy fatty acid (hFA)-sphingolipids facilitate cell signaling. hFA-ceramides contribute to the permeability barrier function of the epidermis. Synthesis of hFA-ceramides are catalyzed by fatty acid 2-hydroxylase (FA2H). Mutations of FA2H causes nervous system disorders leukodystrophy and spastic paraparesis in humans. An antitumor drugPM02734 requires hFA-ceramides in the cell membrane to exhibit its activity. |
|
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
Creative Enzymes
|
| Tel: |
1-516-855-7709 |
| Website: |
www.creative-enzymes.com |
|