| Identification | Back Directory | [Name]
1-desoxyMethylsphingosine (M17:1) | [CAS]
1246303-16-1 | [Synonyms]
1-desoxymethylsphingosine
1-desoxyMethylsphingosine (M17:1)
3-Heptadecen-2-ol, 1-amino-, (2R,3E)-
1-DESOXYMETHYLSPHINGOSINE (M17:1);1-DESOXYMETHYLSPHINGOSINE | [Molecular Formula]
C17H35NO | [MOL File]
1246303-16-1.mol | [Molecular Weight]
269.47 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [form ]
powder | [InChI]
1S/C17H35NO/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-17(19)16-18/h14-15,17,19H,2-13,16,18H2,1H3/b15-14+/t17-/m1/s1 | [InChIKey]
NTZGVZKEAIALQE-IAOULYHDSA-N | [SMILES]
CCCCCCCCCCCCC/C=C/[C@](O)([H])CN |
| Hazard Information | Back Directory | [Uses]
1-desoxymethylsphingosine may be used for the complex preparation with bovine serum albumin for cytotoxicity testing in MN9D dopaminergic neuroblastoma cell line. | [Biological Activity]
1-desoxymethylsphingosine is less neurotoxic compared to 1-desoxysphingosine in dorsal root ganglion neuronscultures Mutations in the palmitoyltransferase (SPT) in hereditary sensory neuropathy type 1 (HSAN-1) due to altered substrate specificity 1-desoxymethylsphinganine and 1-deoxy-sphinganine which are further converted to -deoxy(methyl)-ceramide and 1-deoxy(methyl)-sphingosine (1-deoxy(methyl)-SO). Howeverthey lack the hydroxyl group essential for glycosphingolipid generationresulting in accumulation of intermediate products. |
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| Company Name: |
Merck KGaA
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21-20338288 |
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www.sigmaaldrich.cn |
| Company Name: |
Creative Enzymes
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1-516-855-7709 |
| Website: |
www.creative-enzymes.com |
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