| Identification | Back Directory | [Name]
4-Chloro-3-iodo-1-(4-Methoxybenzyl)-1H-pyrazolo[4,3-c]pyridine | [CAS]
1246349-97-2 | [Synonyms]
4-Chloro-3-iodo-1-(4-methoxybenzyl)
4-Chloro-3-iodo-1-(4-Methoxybenzyl)-1H-pyrazolo[4,3-c]pyridine
1-(4-methoxybenzyl)-4-chloro-3-iodo-1H-pyrazolo[4,3-c]pyridine
4-Chloro-3-iodo-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-c]pyridi...
4-chloro-3-iodo-1-[(4-methoxyphenyl)methyl]pyrazolo[4,3-c]pyridine
4-Chloro-3-iodo-1-[(4-methoxyphenyl)methyl]-1H-pyrazolo[4,3-c]pyridine
1H-Pyrazolo[4,3-c]pyridine, 4-chloro-3-iodo-1-[(4-methoxyphenyl)methyl]- | [Molecular Formula]
C14H11ClIN3O | [MDL Number]
MFCD19689569 | [MOL File]
1246349-97-2.mol | [Molecular Weight]
399.61 |
| Chemical Properties | Back Directory | [Boiling point ]
526.5±50.0 °C(Predicted) | [density ]
1.77 | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [pka]
3.54±0.30(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Synthesis]
4-Chloro-3-iodo-1H-pyrazolo[4,3-c]pyridine (2.00 g, 7.17 mmol) and 1-(chloromethyl)-4-methoxybenzene (2.24 g, 14.3 mmol) were used as raw materials, and 4-chloro-3-iodo-1H-pyrazolo[4,3-c]pyridine was solubilized in dry DMF (30 mL), followed by the addition of KOH (0.800 g 14.3 mmol) and 1-(chloromethyl)-4-methoxybenzene. The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure and the crude product obtained was purified by silica gel column chromatography with the eluent being petroleum ether/ethyl acetate (gradient from 10:1 to 8:1, v/v) to afford the target compound 4-chloro-3-iodo-1-(4-methoxyphenyl)-1H-pyrazolo[4,3-c]pyridine as a white solid (2.4 g, 82% yield). | [References]
[1] Patent: WO2013/139882, 2013, A1. Location in patent: Page/Page column 62
[2] Patent: US2014/288043, 2014, A1. Location in patent: Paragraph 0329
[3] Patent: WO2012/38743, 2012, A1. Location in patent: Page/Page column 82-83
[4] Patent: WO2017/215600, 2017, A1. Location in patent: Page/Page column 32-33 |
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