| Identification | Back Directory | [Name]
(-)-Dihydroguaiaretic acid | [CAS]
124649-78-1 | [Synonyms]
(-)-Dihydroguaiaretic acid
Phenol, 4,4'-[(2R,3R)-2,3-dimethyl-1,4-butanediyl]bis[2-methoxy- | [Molecular Formula]
C20H26O4 | [MOL File]
124649-78-1.mol | [Molecular Weight]
330.42 |
| Chemical Properties | Back Directory | [Melting point ]
86-87 °C | [Boiling point ]
488.3±40.0 °C(Predicted) | [density ]
1.121±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
9.89±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
(-)-Dihydroguaiaretic acid is a Lipoxygenase inhibitor that has antioxidant activity. (-)-Dihydroguaiaretic acid inhibits the oxidation of unsaturated fatty acids and removes free radicals. (-)-Dihydroguaiaretic acid also has anticancer activity with an IC50 value of 7.49 μM (A549 cells)[1][2]. | [References]
[1] Yamauchi S, et al. Antioxidant activity of butane type lignans, secoisolariciresinol, dihydroguaiaretic acid, and 7,7'-oxodihydroguaiaretic acid. Biosci Biotechnol Biochem. 2008 Nov;72(11):2981-6. DOI:10.1271/bbb.80461
[2] Davis R A, et al. Isolation, structure elucidation and cytotoxic evaluation of endiandrin B from the Australian rainforest plant Endiandra anthropophagorum[J]. Bioorganic & medicinal chemistry, 2009, 17(3): 1387-1392. |
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