| Identification | Back Directory | [Name]
PIQCTGMSNWUMAF-UFBJYANTSA-N | [CAS]
1246819-84-0 | [Synonyms]
PIQCTGMSNWUMAF-UFBJYANTSA-N | [Molecular Formula]
C21H13D8FN6O | [MDL Number]
MFCD34567939 | [MOL File]
1246819-84-0.mol | [Molecular Weight]
400.479 |
| Hazard Information | Back Directory | [Description]
Dovitinib-d8 is intended for use as an internal standard for the quantification of dovitinib (Item No. 15220) by GC- or LC-MS. Dovitinib is a multi-kinase inhibitor.1 It inhibits the receptor tyrosine kinases FLT3, CSF1R, and c-Kit (IC50s = 1, 36, and 2 nM, respectively), as well as FGFR1, FGFR3, VEGFR1-3, PDFGRα, and PDGFRβ (IC50s = 8, 9, 10, 13, 8, 27, and 210 nM, respectively). Dovitinib inhibits proliferation of human multiple myeloma cell lines expressing mutant, but not wild-type, FGFR3 (IC50s = 90-550 and >2,500 nM, respectively). It decreases FGF-induced ERK1/2 phosphorylation and induces apoptosis in patient-derived multiple myeloma cells when used at a concentration of 500 nM. Dovitinib (3-300 mg/kg for eight days) inhibits bFGF-induced angiogenesis in a Matrigel™ plug assay in mice.2 It reduces tumor growth in KM12L4A colon, DU145 prostate, and MV4-11 acute myelogenous leukemia mouse xenograft models with ED50 values of 17, 23, and 3 mg/kg per day, respectively. | [Uses]
Compound used in treating melanoma | [storage]
Store at -20°C | [References]
[1] SUZANNE TRUDEL. CHIR-258, a novel, multitargeted tyrosine kinase inhibitor for the potential treatment of t(4;14) multiple myeloma.[J]. Blood, 2005: 2941-2948. DOI: 10.1182/blood-2004-10-3913
[2] PAUL A. RENHOWE*. Design, Structure?Activity Relationships and in Vivo Characterization of 4-Amino-3-benzimidazol-2-ylhydroquinolin-2-ones: A Novel Class of Receptor Tyrosine Kinase Inhibitors[J]. Journal of Medicinal Chemistry, 2008, 52 2: 278-292. DOI: 10.1021/jm800790t |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Pharma Affiliates
|
| Tel: |
172-5066494 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList694812/0_EN.htm |
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