| Identification | Back Directory | [Name]
GLP-1 receptor agonist 5 | [CAS]
1246826-07-2 | [Synonyms]
TT-OAD2 free base
GLP-1 receptor agonist 5
L-Phenylalanine, N-[[(3S,8S)-3-[4-[(3,4-dichlorophenyl)methoxy]phenyl]-2,3,6,7,8,9-hexahydro-7-[(1S)-1-phenylpropyl]-1,4-dioxino[2,3-g]isoquinolin-8-yl]carbonyl]-4-(2,3-dimethyl-4-pyridinyl)- | [Molecular Formula]
C50H47Cl2N3O6 | [MDL Number]
MFCD34469614 | [MOL File]
1246826-07-2.mol | [Molecular Weight]
856.83 |
| Hazard Information | Back Directory | [Uses]
TT-OAD2 free base is a non-peptide glucagon-like peptide-1 (GLP-1) receptor agonist with an EC50 of 5 nM. TT-OAD2 free base has the potential for diabetes treatment[1][2]. | [in vivo]
TT-OAD2 (3 mg/kg; intravenous injection; male human GLP-1 receptor knock-in and knockout mice) treatment induces plasma insulin in an acute IVGTT on humanized GLP-1R knock-in (KI) and GLP-1R knockout (KO) mice[1]. | Animal Model: | Male human GLP-1 receptor knock-in and knockout mice (6-11 months of age) with intravenous glucose tolerance tests[1] | | Dosage: | 3 mg/kg | | Administration: | Intravenous injection (Single dose) | | Result: | Induced plasma insulin.
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| [References]
[1] Zhao P, et al. Activation of the GLP-1 receptor by a non-peptidic agonist. Nature. 2020 Jan;577(7790):432-436. DOI:10.1038/s41586-019-1902-z
[2] Transtech Pharma, et al. Substituted azoanthracene derivatives, pharmaceutical compositions, and methods of use thereof. WO2010114824A1. |
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| Company Name: |
Wuhan Topule
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+86-02787215551 19945035818 |
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www.topule.com/ |
| Company Name: |
Biorbyt Ltd.
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+44 (0)1223 859 353 |
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http://www.biorbyt.com |
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