| Identification | Back Directory | [Name]
BIG ET-1 (22-38) (HUMAN) | [CAS]
124932-61-2 | [Synonyms]
BIG ET-1 (22-38) (HUMAN)
BIG ENDOTHELIN-1 (22-38) (HUMAN)
(22-38)-Big endothelin 1 (human)
BIG ENDOTHELIN-1 FRAGMENT (22-38) (HUMAN)
Big Endothelin-1 fragMent (22-38) (huMan)
Big ET-1 (22-38) (huMan)
VAL-ASN-THR-PRO-GLU-HIS-VAL-VAL-PRO-TYR-GLY-LEU-GLY-SER-PRO-ARG-SER
H-VAL-ASN-THR-PRO-GLU-HIS-VAL-VAL-PRO-TYR-GLY-LEU-GLY-SER-PRO-ARG-SER-OH
VAL-ASN-THR-PRO-GLU-HIS-VAL-VAL-PRO-TYR-GLY-LEU-GLY-SER-PRO-ARG-SER: VNTPEHVVPYGLGSPRS
Big Endothelin-1 fragment (22-38) (human) H-Val-Asn-Thr-Pro-Glu-His-Val-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Arg-Ser-OH
L-Serine, L-valyl-L-asparaginyl-L-threonyl-L-prolyl-L-α-glutamyl-L-histidyl-L-valyl-L-valyl-L-prolyl-L-tyrosylglycyl-L-leucylglycyl-L-seryl-L-prolyl-L-arginyl- | [Molecular Formula]
C80H125N23O25 | [MDL Number]
MFCD00161502 | [MOL File]
124932-61-2.mol | [Molecular Weight]
1808.99 |
| Hazard Information | Back Directory | [Uses]
Big Endothelin-1 Fragment (22-38) (Human) is a therapeutic peptide. It was useful for finding a method to protect peptides from peptidase activity in vivo. | [in vivo]
Big Endothelin-1 (22-38), human (3 nM/kg; intra-arterial injection; single dose) produces a significant rise in left ventricular systolic pressure (LVSP) in anesthetized rabbits, and is enhanced by cyclooxygenase inhibitor Indomethacin.html" class="link-product" target="_blank">Indomethacin (HY-14397) (5 mg/kg i.v.) significantly[3].
Big Endothelin-1 (22-38), human (3 nM/kg; intravascular method; single dose), has no antiaggregatory properties for platelet induced by ADP in rabbits[3].
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