125-28-0

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125-28-0 Structure

Identification	Back Directory
[Name] DIHYDROCODEINE TRIFLUOROACETATE
[CAS] 125-28-0
[Synonyms] Didrate Drocode Nadeine Parzone Drocade Novcodin Dihydrin Cohydrin Dehacodin Novicodin Rapacodin Rapocodin Paracodin Paracodine Novicondin Hydrocodin DH-codeine Codhydrine Novicodine NSC 231319 α-Hydrocodol Hydrocodeine 6α-Hydrocodol Dihydrokodein Dihydroneopine alpha-Hydrocodol Codeine, dihydro- 6alpha-Hydrocodol 7,8-dihydro-codein 7,8-Dihydrocodeine 6-alpha-hydrocodol Dihydrocodeine HCl 8,14-Dihydroneopine Dihydrocodeine (CRM) RBOXVHNMENFORY-DNJOTXNNSA-N Codeine, 7,8-dihydro- (6CI) DIHYDROCODEINE TRIFLUOROACETATE Dihydrocodeine hydrochloride solution Dihydrocodeine (base and/or unspecified salts) 6-Hydroxy-3-methoxy-N-methyl-4,5-epoxymorphinan 4,5alpha-Epoxy-3-methoxy-17-methylmorphinan-6alpha-ol Morphinan-6α-ol, 4,5α-epoxy-3-methoxy-17-methyl- (8CI) 4,5-alpha-epoxy-3-methoxy-17-methyl-morphinan-6-alpha-o Morphinan-6-ol, 4,5-epoxy-3-methoxy-17-methyl-, (5α,6α)- Morphinan-6alpha-ol, 4,5alpha-epoxy-3-methoxy-17-methyl- Morphinan-6-ol, 4,5-epoxy-3-methoxy-17-methyl-, (5alpha,6alpha)- 3-Methoxy-12-methyl-5,6,7,7α,8,9-hexahydro-4aH-8,9c-iminoethanophenanthro[4,5-bcd]furan-5-ol
[EINECS(EC#)] 204-732-3
[Molecular Formula] C20H24F3NO4
[MDL Number] MFCD02253008
[MOL File] 125-28-0.mol
[Molecular Weight] 399.4

Chemical Properties	Back Directory
[Melting point ] 112-113°
[Boiling point ] bp15 248°
[density ] 1.1412 (rough estimate)
[refractive index ] 1.5740 (estimate)
[Fp ] 9℃
[storage temp. ] 2-8°C
[solubility ] DMF: 20 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 10 mg/ml
[form ] A neat solid
[EPA Substance Registry System] Morphinan-6-ol, 4,5-epoxy-3-methoxy-17-methyl-, (5?,6?)- (125-28-0)

Safety Data	Back Directory
[Hazard Codes ] F,T
[Risk Statements ] 11-23/24/25-39/23/24/25
[Safety Statements ] 7-16-36/37-45
[RIDADR ] UN1230 - class 3 - PG 2 - Methanol, solution
[Safety Profile] Poison by ingestion, intravenous, and subcutaneous routes. Human systemic effects by ingestion and subcutaneous routes: somnolence, miosis (pupillary constriction), and respiratory depression. An analgesic. Can cause drug dependency with repeated doses. When heated to decomposition it emits toxic fumes of NOx. See also CODEINE.

Hazard Information	Back Directory
[Originator] Bicodein,Uquifa
[Definition] ChEBI: Dihydrocodeine is a morphinane alkaloid.
[Manufacturing Process] The codein was reduced by hydrogen in the presence catalyst Pt (or Pd, or Ni) and 7,8-dihydrocodein was obtained. To the 7,8-dihydrocodein tartaric acid was added and mixed, in the result 7,8- dihydrocodein bitartrate was obtained.
[Therapeutic Function] Antitussive, Narcotic analgesic

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