| Identification | Back Directory | [Name]
caramiphen hydrochloride | [CAS]
125-85-9 | [Synonyms]
G 2747
Parpanil
Parpanit
Panparnit
caramiphen hydrochloride
Pentaphene hydrochloride
Caramiphenium chloride salt
Pentoxyverine EP Impurity B HCl
Pentoxyverine Impurity(Hydrochloride)
Caramiphen hydrochloride >=98% (HPLC)
Pentoxyverine Impurity 3(Hydrochloride)
Pentoxyverine EP Impurity B Hydrochloride
Pentoxyverine Impurity B HCl (Caramiphen HCl)
Pentoxyverine Hydrogen Citrate Impurity B as Hydrochloride
Pentoxyverine Hydrogen Citrate EP Impurity B as Hydrochloride
2-(Diethylamino)ethyl 1-phenylcyclopentane-1-carboxylate hydrochloride | [EINECS(EC#)]
204-758-5 | [Molecular Formula]
C18H27NO2.ClH | [MDL Number]
MFCD00242608 | [MOL File]
125-85-9.mol | [Molecular Weight]
325.877 |
| Chemical Properties | Back Directory | [Melting point ]
145-146° | [storage temp. ]
2-8°C | [solubility ]
H2O: ≥5mg/mL | [form ]
powder | [color ]
white to beige | [Water Solubility ]
H2O: ≥5mg/mL | [InChI]
1S/C18H27NO2.ClH/c1-3-19(4-2)14-15-21-17(20)18(12-8-9-13-18)16-10-6-5-7-11-16;/h5-7,10-11H,3-4,8-9,12-15H2,1-2H3;1H | [InChIKey]
MUPNXGNOIBYHSG-UHFFFAOYSA-N | [SMILES]
Cl.CCN(CC)CCOC(=O)C1(CCCC1)c2ccccc2 |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
22 | [WGK Germany ]
3 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral | [Toxicity]
LD50 i.p. in rats: 209 mg/kg (Kraatz) |
| Hazard Information | Back Directory | [Uses]
Caramiphen hydrochloride has been used to test its inhibitory effect on voltage-gated Na+ currents using the patch-clamp method. | [Biochem/physiol Actions]
Caramiphen hydrochloride is non-narcotic and possesses many biological functionalities of being antitussive, anticonvulsive, and neuroprotective. It induces sensory block and displays less toxicity when compared to bupivacaine. The local anesthetic functionality of caramiphen is mediated by its inhibitory effect on voltage-gated Na+ currents. | [in vivo]
Caramiphen (30-100 mg/kg, i.m.) hydrochloride protects against soman-induced behavioural seizures and neuronal degeneration in rats[1].
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