| Identification | Back Directory | [Name]
Acetic acid, 2-[3-[1-[[2-(3,4-dichlorophenyl)acetyl]methylamino]-2-(1-pyrrolidinyl)ethyl]phenoxy]- | [CAS]
125190-72-9 | [Synonyms]
Acetic acid, 2-[3-[1-[[2-(3,4-dichlorophenyl)acetyl]methylamino]-2-(1-pyrrolidinyl)ethyl]phenoxy]- | [Molecular Formula]
C23H26Cl2N2O4 | [MOL File]
125190-72-9.mol | [Molecular Weight]
465.37 |
| Hazard Information | Back Directory | [Description]
ICI 204448 is a potent and peripherally selective κ-opioid agonist, with possible uses in the treatment of heart attack as well as anti-itching effects. | [Uses]
ICI-204448 free acid is a κ-opioid agonist with limited access to the CNS, ICI-204448 free acid can displace the binding of the kappa-opioid ligand 3H-bremazocine from guinea pig cerebellum membranes[1]. | [Definition]
ChEBI: 2-[3-[1-[[2-(3,4-dichlorophenyl)-1-oxoethyl]-methylamino]-2-(1-pyrrolidinyl)ethyl]phenoxy]acetic acid is a monocarboxylic acid. | [References]
[1] J S Shaw, et, al. ICI 204448: a kappa-opioid agonist with limited access to the CNS. Br J Pharmacol. 1989, 96, 4. DOI:10.1111/j.1476-5381.1989.tb11911.x |
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