| Hazard Information | Back Directory | [Description]
HDAC-IN-4 is a selective HDAC6 and HDAC10 inhibitor that has antitumor activity. | [Uses]
HDAC-IN-4 is a selective HDAC6 and HDAC10 inhibitor with pIC50s of 7.2 and 6.8 in BRET assay, respectively. Antitumoral activity[1]. | [References]
[1] Géraldy M, et al. Selective Inhibition of Histone Deacetylase 10: Hydrogen Bonding to the Gatekeeper Residue is Implicated. J Med Chem. 2019 May 9;62(9):4426-4443. DOI:10.1021/acs.jmedchem.8b01936 |
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