| Identification | Back Directory | [Name]
GLY-ARG P-NITROANILIDE DIHYDROCHLORIDE | [CAS]
125455-61-0 | [Synonyms]
GR-pNA
GR
Gly-Arg-4-NA
H-GLY-ARG-PNA 2HCL
H-Gly-Arg-Pna dihydrochloride
GLY-ARG-4-NA;GR-PNAGR; P-NITROANILIDE
GLY-ARG P-NITROANILIDE DIHYDROCHLORIDE
Gly-Arg-p-nitroanilide dihydrochloride unokinase and plasmin substrate | [Molecular Formula]
C14H23Cl2N7O4 | [MDL Number]
MFCD00083360 | [MOL File]
125455-61-0.mol | [Molecular Weight]
424.28 |
| Chemical Properties | Back Directory | [storage temp. ]
−20°C | [solubility ]
DMF: 20mg/mL; DMSO: 3mg/mL; PBS (pH 7.2): 3mg/mL | [form ]
A solid | [InChIKey]
UMNMBKCWESYUMR-LCJJWKFENA-N | [SMILES]
C1(C=CC([N+]([O-])=O)=CC=1)NC(=O)[C@@H](NC(=O)CN)CCCNC(=N)N.Cl.Cl |&1:12,r| |
| Hazard Information | Back Directory | [Description]
H-Gly-Arg-pNA is a colorimetric substrate for thrombin. Thrombin preferentially binds to and cleaves the Gly-Arg (GR) peptide sequence to release p-nitroanilide (pNA), which can be quantified by colorimetric detection at 405 nm as a measure of thrombin activity. | [Uses]
H-Gly-Arg-pNA hydrochloride (GR-pNA hydrochloride) is a colorimetric substrate for thrombin. H-Gly-Arg-pNA is preferentially bound by thrombin and cleaves the Gly-Arg (GR) peptide sequence, releasing p-nitroaniline (pNA) that can be detected colorimetrically at 405 nm. H-Gly-Arg-pNA hydrochloride is used as a fluorescent dye to measure thrombin activity[1]. | [storage]
Store at -20°C | [References]
[1] Hortin G L, et al. Macromolecular chromogenic substrates for measuring proteinase activity[J]. Clinical chemistry, 2001, 47(2): 215-222. PMID:11159769 |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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