| Identification | Back Directory | [Name]
SIBUTRAMINE HYDROCHLORIDE MONOHYDRATE | [CAS]
125494-59-9 | [Synonyms]
SibutramineHClH2O
SIBUTRAMINE HCL HYDRATE
)-SibutraMine-d6 HCl H2O
SIBUTRAMINE HCL MONOHYDRATE
BTS-54524, Reductil, Meridia
SIBUTRAMINE HYDROCHLORIDE HYDRATE
Sibutramine hydrochloride solution
SIBUTRAMINE HYDROCHLORIDE MONOHYDRATE
Sibutramine Hydrochloride CIV (125 mg)
Sibutramine monohydrate hydrochloride
1-[1-(4-chlorophenyl)cyclobutyl]-N,N,3-trimethylbutan-1-amine hydrate hydrochloride
1-[1-(4-chlorophenyl)cyclobutyl]-N,N,3-trimethyl-butan-1-amine hydrate hydrochloride
[1-[1-(4-chlorophenyl)cyclobutyl]-3-methyl-butyl]-dimethyl-amine hydrate hydrochloride
1-(4-Chlorophenyl)-N,N-dimethyl-α-(2-methylpropyl)cyclobutanemethanamine hydrochloride
1-(4-Chlorophenyl)-N,N-dimethyl-alpha-(2-methylpropyl)cyclobutanemethanamine hydrochloride monohydrate
CyclobutaneMethanaMine,1-(4-chlorophenyl)-N,N-diMethyl-a-(2-Methylpropyl)-, hydrochloride, hydrate (1:1:1)
Meridia, Reductil, 1-(4-Chlorophenyl)-N,N-dimethyl-alpha-(2-methylpropyl)cyclobutanemethanamine monohydrate hydrochloride | [EINECS(EC#)]
200-659-6 | [Molecular Formula]
C17H29Cl2NO | [MDL Number]
MFCD04039806 | [MOL File]
125494-59-9.mol | [Molecular Weight]
334.32 |
| Chemical Properties | Back Directory | [Appearance]
White Solid | [Melting point ]
193-195.5°C | [Fp ]
9℃ | [storage temp. ]
Room temp | [solubility ]
DMSO: >30mg/mL | [form ]
solid | [color ]
white |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
A serotonin and noradrenaline reuptake inhibitor (SNR). Decreases calorie intake and increases energy expenditure | [Uses]
antihyperlipidemic | [Uses]
antiobesity agent;neurotransmitter reuptake inhibitor | [Description]
Sibutramine was introduced as Meridia in the US for the control of
obesity, in conjunction with a reduced-calorie diet. Sibutramine can be prepared
in four steps from 4-chlorobenzyl cyanide. Sibutramine acts as a serotonin and
noradrenaline reuptake inhibitor ; in animal studies, it reduces energy intake by
creating a satieted feeling and increases energy expenditure by enhancing
thermogenesis. In a clinical study in obese patients treated with 10 or 15 mg of
Sibutramine once-daily, meaningful weight loss was sustained for 12 months ;
an additional study demonstrated a lack of abuse potential. An appreciable part
of Sibutramine's effect would also be due to its 2N-mono and didesmethylmetabolites,
which are very potent monoamine reuptake inhibitors
themselves. | [Originator]
Knoll (Germany) | [Brand name]
Meridia (Abbott);Meridia, Reductil. |
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