| Identification | Back Directory | [Name]
JNJ-46281222 | [CAS]
1254980-38-5 | [Synonyms]
JNJ-46281222
JNJ 46281222,JNJ46281222
1,2,4-Triazolo[4,3-a]pyridine, 3-(cyclopropylmethyl)-7-[(4-phenyl-1-piperidinyl)methyl]-8-(trifluoromethyl)- | [Molecular Formula]
C23H25F3N4 | [MDL Number]
MFCD32689436 | [MOL File]
1254980-38-5.mol | [Molecular Weight]
414.47 |
| Hazard Information | Back Directory | [Uses]
JNJ-46281222 is an metabotropic glutamate (mGlu) 2-selective, highly potent PAM (positive allosteric modulator) with nanomolar affinity (Kd = 1.7 nM) and a high modulatory potency (pEC50 = 7.71)[1]. | [IC 50]
mGluR2: 1.7 nM (Kd) | [References]
[1] Doornbos ML,et al. Molecular mechanism of positive allosteric modulation of the metabotropic glutamate receptor 2 by JNJ-46281222.Br J Pharmacol. 2016 Feb;173(3):588-600. DOI:10.1111/bph.13390 |
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| Company Name: |
cjbscvictory
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| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
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