| Identification | Back Directory | [Name]
spacer 18 Phosphoramidite | [CAS]
125607-09-2 | [Synonyms]
spacer 18 Phosphoramidite
DMT-PEG Phosphoramidite 18
Hexaethylene glycol phosphoramidite
Spacer 18(PEG)-DMT CE Phosphoramidite
1,1-bis(4-methoxyphenyl)-1-phenyl-2,5,8,11,14,17-hexaoxanonadecan-19-yl (2-cyanoethyl) diisopropylphosphoramidite
Phosphoramidous acid, N,N-bis(1-methylethyl)-, 19,19-bis(4-methoxyphenyl)-19-phenyl-3,6,9,12,15,18-hexaoxanonadec-1-yl 2-cyanoethyl ester | [Molecular Formula]
C42H61N2O10P | [MOL File]
125607-09-2.mol | [Molecular Weight]
784.91 |
| Chemical Properties | Back Directory | [Boiling point ]
763.6±60.0 °C(Predicted) | [storage temp. ]
Storage temp. 2-8°C | [solubility ]
good in most organic solvents | [form ]
Liquid | [pka]
3.53±0.70(Predicted) | [color ]
Colorless to light yellow | [Appearance]
colorlessoryellowish oil |
| Hazard Information | Back Directory | [Description]
Spacer phosphoramidite 18 (hexaethylene glycol phosphoramidite) is an amidite reagent for oligonucleotide synthesis. It provides a long hydrophilic linker that can be used for the synthesis of Scorpion-type qPCR probes, for spacing biotin from oligo strand, and for other applications requiring spatial separation of modifier and oligo | [Uses]
Hexaethylene glycol phosphoramidite (Spacer Phosphoramidite 18) is an amidite reagent for oligonucleotide synthesis. Hexaethylene glycol phosphoramidite can be used as a linker in synthesis of nucleotide chain and qPCR probes[1][2]. | [References]
[1] Longcheng Li, Moorim KANG. Multi-valent oligonucleotide agent and methods of use thereof. WO2022166849A1
[2] Schaudy E, Lietard J, Somoza MM. Sequence Preference and Initiator Promiscuity for De Novo DNA Synthesis by Terminal Deoxynucleotidyl Transferase. ACS Synth Biol. 2021 Jul 16;10(7):1750-1760. DOI:10.1021/acssynbio.1c00142 |
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