| Identification | Back Directory | [Name]
Imidazo[5,1-a]isoquinoline-3-carboxamide, N-(1,1-dimethylethyl)-N-ethyl-5,6-dihydro-8-methoxy-9-(1-methylethoxy)-1-(2-thienyl)- | [CAS]
1256776-89-2 | [Synonyms]
FSHR agonist 1
Imidazo[5,1-a]isoquinoline-3-carboxamide, N-(1,1-dimethylethyl)-N-ethyl-5,6-dihydro-8-methoxy-9-(1-methylethoxy)-1-(2-thienyl)- | [Molecular Formula]
C26H33N3O3S | [MOL File]
1256776-89-2.mol | [Molecular Weight]
467.62 |
| Chemical Properties | Back Directory | [Boiling point ]
624.8±65.0 °C(Predicted) | [density ]
1.20±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
3.27±0.20(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
FSHR agonist 1 is a high affinity and allosteric follicle stimulating hormone receptor (FSHR) agonist with a pEC50 of 7.72. FSHR agonist 1 formes extensive interactions with the TMD to directly activate FSHR[1]. | [References]
[1] Jia Duan, et al. Universal mechanism of hormone and allosteric agonist mediated activation of glycoprotein hormone receptors as revealed by structures of follicle stimulating hormone receptor. biorxiv. August 01, 2022. |
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