| Identification | Back Directory | [Name]
2H-Imidazo[4,5-c]quinolin-2-one, 1-(1,3-dimethyl-1H-pyrazol-4-yl)-1,3-dihydro-3-methyl-8-[6-methyl-5-(1-methylethoxy)-3-pyridinyl]- | [CAS]
1257547-40-2 | [Synonyms]
PI3K-IN-37
2H-Imidazo[4,5-c]quinolin-2-one, 1-(1,3-dimethyl-1H-pyrazol-4-yl)-1,3-dihydro-3-methyl-8-[6-methyl-5-(1-methylethoxy)-3-pyridinyl]- | [Molecular Formula]
C25H26N6O2 | [MOL File]
1257547-40-2.mol | [Molecular Weight]
442.51 |
| Chemical Properties | Back Directory | [Boiling point ]
619.8±65.0 °C(Predicted) | [density ]
1.31±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
5.65±0.20(Predicted) | [color ]
Light yellow to light brown |
| Hazard Information | Back Directory | [Uses]
PI3K-IN-37 (Example 84.1) is a PI3K α/β/δ inhibitor with IC50s of 6, 8, 4 nM, respectively. PI3K-IN-37 can also inhibit mTOR (IC50=4 nM)[1]. | [IC 50]
PI3Kδ: 4 nM (IC50); mTOR: 4 nM (IC50); PI3Kα: 6 nM (IC50); PI3Kβ: 8 nM (IC50) | [References]
[1] FURET Pascal, et al. 1H-IMIDAZO[4,5-c]QUINOLINONE DERIVATIVES. WO2010139731A1. |
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