| Identification | Back Directory | [Name]
Lactacystin, Synthetic - CAS 1258004-00-0 - Calbiochem | [CAS]
1258004-00-0 | [Synonyms]
Lactacystin, Synthetic - CAS 1258004-00-0 - Calbiochem | [Molecular Formula]
C15H24N2O7S | [MOL File]
1258004-00-0.mol | [Molecular Weight]
376.42 |
| Chemical Properties | Back Directory | [Boiling point ]
714.9±60.0 °C(Predicted) | [density ]
1.367±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: 50mg/mL
water: soluble | [form ]
solid | [pka]
3.11±0.10(Predicted) | [color ]
white |
| Hazard Information | Back Directory | [General Description]
An irreversible proteasome inhibitor. A Streptomyces metabolite that acts as a highly specific inhibitor of the 20S proteasome (MCP; multicatalytic proteinase complex) (IC50 = 500 nM for 20S proteasome). Blocks proteasome activity by targeting the catalytic β-subunit. Acts as a covalent inhibitor of the chymotrypsin and trypsin-like activities of the proteasome. Induces neurite outgrowth in Neuro 2A mouse neuroblastoma cells beyond theG1 phase of the cell cycle. Reported to induce apoptosis in human monoblast U937 cells. Also inhibits NF-κB activation (IC50 = 10 μM) | [Biochem/physiol Actions]
Target IC50: 500 nM against 20S proteasome; 10 μM against NF-κB activation |
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| Company Name: |
Merck Millipore
|
| Tel: |
1-400-889-1988 400-889-1988 |
| Website: |
http://www.merckmillipore.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|