ChemicalBook--->CAS DataBase List--->125911-68-4

125911-68-4

125911-68-4 Structure

125911-68-4 Structure
IdentificationBack Directory
[Name]

SAMS PEPTIDE
[CAS]

125911-68-4
[Synonyms]

SAMStide
SAMS PEPTIDE
HMRSAMSGLHLVKRR
HIS-MET-ARG-SER-ALA-MET-SER-GLY-LEU-HIS-LEU-VAL-LYS-ARG-ARG
H-HIS-MET-ARG-SER-ALA-MET-SER-GLY-LEU-HIS-LEU-VAL-LYS-ARG-ARG-OH
(SER76,ARG86,87)-ACC-ALPHA (73-87) (DEPHOSPHORYLATED) (E COLI, RAT)
(SER77,ARG87,88)-ACC-ALPHA (74-88) (DEPHOSPHORYLATED) (BOVINE, OVINE)
(SER76,ARG86,87)-ACETYL-COA CARBOXYLASE 1 (73-87) (DEPHOSPHORYLATED) (E COLI, RAT)
(SER77,ARG87,88)-ACETYL-COA CARBOXYLASE 1 (74-88) (DEPHOSPHORYLATED) (BOVINE, OVINE)
L-Arginine,L-histidyl-L-methionyl-L-arginyl-L-seryl-L-alanyl-L-methionyl-L-serylglycyl-L-leucyl-L-histidyl-L-leucyl-L-valyl-L-lysyl-L-arginyl-
(Ser76,Arg86·87)-ACC-a (73-87) (dephosphorylated) (E. coli, rat), (Ser76,Arg86·87)-Acetyl-CoA Carboxylase 1 (73-87) (dephosphorylated) (E. coli, rat), (Ser77,Arg87·88)-ACC-a (74-88) (dephosphorylated) (bovine, ovine), (Ser77,Arg87·88)-Acetyl-CoA Carboxylase 1 (74-88) (dephosphorylated) (bovine, ovine)
[Molecular Formula]

C74H131N29O18S2
[MDL Number]

MFCD02682924
[MOL File]

125911-68-4.mol
[Molecular Weight]

1779.15
Chemical PropertiesBack Directory
[density ]

1.47±0.1 g/cm3(Predicted)
[storage temp. ]

Desiccate at -20°C
[solubility ]

DMF: 15 mg/ml; DMSO: 15 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 10 mg/ml
[form ]

powder
[color ]

white to off-white
[biological source]

synthetic
[Sequence]

His-Met-Arg-Ser-Ala-Met-Ser-Gly-Leu-His-Leu-Val-Lys-Arg-Arg
Hazard InformationBack Directory
[Uses]

Useful as a substrate for AMPK kinases.
[General Description]

SAMS Peptide trifluoroacetate salt is a peptide having a putative AMPK phosphorylation site (Ser568) of carbohydrate-responsive element-binding protein (ChREBP) and a peptide containing a cAMP-dependent protein kinase (PKA) phosphorylation site (Thr666).
[Biochem/physiol Actions]

SAMS Peptide is a synthetic substrate selective for AMP-activated protein kinase (AMPK). Its sequence is based on acetyl-CoA carboxylase, which is phosphorylated exclusively by the AMPK, but with serine (Ser)-79 replaced by alanine SAMS peptide is more specific for AMPK than acetyl-CoA carboxylase itself.
[storage]

Desiccate at -20°C
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