| Identification | Back Directory | [Name]
L-Leucyl-L-prolyl-L-alanylglycyl-L-α-glutamyl-L-lysyl-L-prolyl-L-α-glutamyl-L-α-glutamylglycyl-L-α-glutamyl-L-prolyl-L-valyl-L-leucyl-L-histidyl-L-valyl-L-α-glutamyl-L-alanyl-L-α-glutamyl-L-prolylglycyl-L-phenylalanyl-L-threonyl-L-alanyl-L-arginyl-L-α-aspartyl-L-lysyl-L-glutamic acid | [CAS]
1259384-47-8 | [Synonyms]
L-Leucyl-L-prolyl-L-alanylglycyl-L-α-glutamyl-L-lysyl-L-prolyl-L-α-glutamyl-L-α-glutamylglycyl-L-α-glutamyl-L-prolyl-L-valyl-L-leucyl-L-histidyl-L-valyl-L-α-glutamyl-L-alanyl-L-α-glutamyl-L-prolylglycyl-L-phenylalanyl-L-threonyl-L-alanyl-L-arginyl-L-α-aspartyl-L-lysyl-L-glutamic acid | [Molecular Formula]
C133H207N35O46 | [MOL File]
1259384-47-8.mol | [Molecular Weight]
3032.28 |
| Chemical Properties | Back Directory | [density ]
1.52±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [form ]
Solid | [color ]
White to off-white | [Sequence]
Leu-Pro-Ala-Gly-Glu-Lys-Pro-Glu-Glu-Gly-Glu-Pro-Val-Leu-His-Val-Glu-Ala-Glu-Pro-Gly-Phe-Thr-Ala-Arg-Asp-Lys-Glu |
| Hazard Information | Back Directory | [Uses]
Synstatin (92-119) is an anti-tumor agent that inhibits angiogenesis and cancer cell invasion. Synstatin (92-119) down-regulates integrin α?β3 and reduces the activation of angiogenic growth factors VEGF and FGF-2[1][2]. | [References]
[1] Metwaly HA, et al. Inhibition of the signaling pathway of syndecan-1 by synstatin: A promising anti-integrin inhibitor of angiogenesis and proliferation in HCC in rats. Arch Biochem Biophys. 2018 Aug 15;652:50-58. DOI:10.1016/j.abb.2018.06.007
[2] Rapraeger AC. Synstatin: a selective inhibitor of the syndecan-1-coupled IGF1R-αvβ3 integrin complex in tumorigenesis and angiogenesis. FEBS J. 2013 May;280(10):2207-15. DOI:10.1111/febs.12160 |
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