| Identification | Back Directory | [Name]
L 659837 | [CAS]
125989-10-8 | [Synonyms]
837
T24312
L 659837
837 L 659
L-659,837 L 659,837
Cyclo[(αS,3R)-3-amino-α-(2-methylpropyl)-2-oxo-1-pyrrolidineacetyl-L-methionyl-L-glutaminyl-L-tryptophyl-L-phenylalanyl] | [Molecular Formula]
C40H52N8O7S | [MOL File]
125989-10-8.mol | [Molecular Weight]
788.96 |
| Chemical Properties | Back Directory | [Boiling point ]
1234.8±65.0 °C(Predicted) | [density ]
1.34±0.1 g/cm3(Predicted) | [pka]
13.05±0.70(Predicted) | [Sequence]
Cyclo(Gln-Trp-Phe-{(R)Gly(ANC-2)}-Leu-Met) |
| Hazard Information | Back Directory | [Description]
L 659837 is an ANC-2 is a lactam; tackykinin antagonist. | [Uses]
L-659837 is a NK2 receptor antagonist, and can antagonize GR 64349 (HY-P1278)-induced contraction. L-659837 can be used for study of urinary bladder disorders[1]. | [References]
[1] Palea S, et al. Pharmacological characterization of tachykinin NK2 receptors on isolated human urinary bladder, prostatic urethra and prostate. J Pharmacol Exp Ther. 1996;277(2):700-705. PMID:8627548 |
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