| Identification | Back Directory | [Name]
Bromoacetamido-PEG4-NHS ester | [CAS]
1260139-70-5 | [Synonyms]
CAS_1260139-70-5
BrCH2CONH-PEG4-NHS ester
Bromoacetamido-PEG4-NHS ester
Bromoacetamido-PEG5-NHS ester
2,5-Dioxopyrrolidin-1-yl 1-bromo-2-oxo-6,9,12,15-tetraoxa-3-azaoctadecan-18-oate
4,7,10,13-Tetraoxa-16-azaoctadecanoic acid, 18-bromo-17-oxo-, 2,5-dioxo-1-pyrrolidinyl ester | [Molecular Formula]
C17H27BrN2O9 | [MDL Number]
MFCD20229159 | [MOL File]
1260139-70-5.mol | [Molecular Weight]
483.31 |
| Hazard Information | Back Directory | [Description]
Bromoacetamido-PEG4-NHS ester is a PEG linker containing a bromide group and an NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. | [Uses]
Bromoacetamido-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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Borenpharm Co., Ltd
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Henan Alfachem Co.,Ltd.
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