| Identification | Back Directory | [Name]
4-Chloro-6,7-dihydro-5H-cyclopenta-pyridin-7-OL | [CAS]
126053-15-4 | [Synonyms]
4-Chloro-6,7-dihydro-5H-[1]pyrindin-7-ol
4-chloro-5H,6H,7H-cyclopenta[b]pyridin-7-ol
4-Chloro-6,7-dihydro-5H-cyclopenta-pyridin-7-OL
4-CHLORO-6,7-DIHYDRO-5H-CYCLOPENTA[B]PYRIDIN-7-OL
5H-Cyclopenta[b]pyridin-7-ol, 4-chloro-6,7-dihydro-
4-Chloro-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridine
4-Chloro-6,7-dihydro-5H-cyclopenta-pyridin-7-OL ISO 9001：2015 REACH | [Molecular Formula]
C8H8ClNO | [MDL Number]
MFCD13152137 | [MOL File]
126053-15-4.mol | [Molecular Weight]
169.61 |
| Chemical Properties | Back Directory | [Boiling point ]
311.1±42.0 °C(Predicted) | [density ]
1.405 | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [pka]
12.83±0.20(Predicted) | [Appearance]
Light brown to brown Solid |
| Hazard Information | Back Directory | [Synthesis]
The general procedure for the synthesis of 4-chloro-6,7-dihydro-5H-cyclopenta[B]pyridin-7-ol from 4-chloro-5,6-dihydro-7H-cyclopenta[B]pyridin-7-one was as follows: sodium tetrahydroborate (1.92 g, 50.67 mmol) was added batchwise to a methanol (80 mL) solution of intermediate 1 (7.72 g, 46.06 mmol) at 5 °C ) solution. The reaction mixture was stirred overnight at room temperature and subsequently poured into water. The mixture was extracted three times with ethyl acetate. The organic layers were combined, washed sequentially with water and sodium chloride solution, separated and dried over magnesium sulfate, filtered and the solvent concentrated to give Intermediate 3 (6.38 g, 81.7% yield, as a 50/50 RS mixture). The product can be used directly in subsequent reactions without further purification. | [References]
[1] Patent: WO2010/89327, 2010, A2. Location in patent: Page/Page column 42 |
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