| Identification | Back Directory | [Name]
L-TETRANDRINE | [CAS]
1263-79-2 | [Synonyms]
PHAENTHINE
Pheanthine
L-TETRANDRINE
16H-1,24:6,9-Dietheno-11,15-metheno-2H-pyrido[2',3':17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinoline, 3,4,4a,5,16a,17,18,19-octahydro-12,21,22,26-tetramethoxy-4,17-dimethyl-, (4aR,16aR)- | [Molecular Formula]
C38H42N2O6 | [MDL Number]
MFCD00134987 | [MOL File]
1263-79-2.mol | [Molecular Weight]
622.75 |
| Hazard Information | Back Directory | [Uses]
Pheanthine (Compound 2) is an antiplasmodial agent, that inhibits chloroquine-resistant Plasmodium falciparum K-1 (IC50 is 0.8 μM) and chloroquine-sensitive P. falciparum strain NF54 A19A (IC50 of 0.03 μM). Pheanthine exhibits low cytotoxicity in human lung fibrosblast (MRC-5, IC50 is 11.2 μM) and macrophages (PMM, IC50 is 8 μM)[1]. | [References]
[1] Cimanga Kanyanga R., et al.,Isolation and structure elucidation of two antiprotozoal bisbenzylisoquinoline alkaloids from Triclisia gilletii stem bark. Phytochemistry Letters. 2018. |
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