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1263044-88-7

1263044-88-7 Structure

1263044-88-7 Structure
IdentificationBack Directory
[Name]

2,5-dioxopyrrolidin-1-yl 1-(3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)phenyl)-1-oxo-5,8,11,14-tetraoxa-2-azaheptadecan-17-oate
[CAS]

1263044-88-7
[Synonyms]

Mal-Ph-CONH-PEG4-?NHS ester
2,5-dioxopyrrolidin-1-yl 1-(3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)phenyl)-1-oxo-5,8,11,14-tetraoxa-2-azaheptadecan-17-oate
Propanoic acid, 3-[[13-[3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)phenyl]-13-oxo-3,6,9-trioxa-12-azatridec-1-yl]oxy]-, 2,5-dioxo-1-pyrrolidinyl ester
[Molecular Formula]

C26H31N3O11
[MOL File]

1263044-88-7.mol
[Molecular Weight]

561.54
Chemical PropertiesBack Directory
[form ]

Liquid
[color ]

Colorless to light yellow
Hazard InformationBack Directory
[Uses]

Mal-Ph-CONH-PEG4- NHS ester is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
[IC 50]

Non-cleavable Linker
[References]

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268
Spectrum DetailBack Directory
[Spectrum Detail]

2,5-dioxopyrrolidin-1-yl 1-(3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)phenyl)-1-oxo-5,8,11,14-tetraoxa-2-azaheptadecan-17-oate(1263044-88-7)1HNMR
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