| Identification | Back Directory | [Name]
Skf 107457 | [CAS]
126333-28-6 | [Synonyms]
Aids000504
Aids-000504
Ala-Ala-Phe.psi.[ch(OH)ch2]Gly-Val-val-och3
5-(L-Alanyl-L-alanylamino)-4-hydroxy-6-phenylhexanoic acid, methyl valyl-valyl amide
L-Valine, L-alanyl-L-alanyl-(.gamma.S, .delta.S)-.delta.-amino-.gamma.-hydroxybenzenehexanoyl-L-valyl-, methyl ester | [Molecular Formula]
C29H47N5O7 | [MOL File]
126333-28-6.mol | [Molecular Weight]
577.72 |
| Hazard Information | Back Directory | [Description]
SKF-107457 is a HIV protease type 1 inhibitor, and are hexapeptide substrate analogues with the scissile bond being replaced by a hydroxyethylene isostere. | [Uses]
SKF107457 is an HIV-1 protease inhibitor that can be used in AIDS research[1][2]. | [References]
[1] Verkhivker GM. Empirical free energy calculations of human immunodeficiency virus type 1 protease crystallographic complexes. II. Knowledge-based ligand-protein interaction potentials applied to thermodynamic analysis of hydrophobic mutations. Pac Symp Biocomput. 1996:638-52. PMID:9390264
[2] Fitzgerald P M D. HIV protease-ligand complexes: Current Opinion in Structural Biology 1993, 3: 868–874[J]. Current Opinion in Structural Biology, 1993, 3(6): 868-874. |
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