| Identification | Back Directory | [Name]
1-Piperazinecarboxylic acid, 4-[2-(3,4-dichlorophenyl)acetyl]-3-(1-pyrrolidinylmethyl)-, methyl ester | [CAS]
126766-31-2 | [Synonyms]
1-Piperazinecarboxylic acid, 4-[2-(3,4-dichlorophenyl)acetyl]-3-(1-pyrrolidinylmethyl)-, methyl ester | [Molecular Formula]
C19H25Cl2N3O3 | [MOL File]
126766-31-2.mol | [Molecular Weight]
414.33 |
| Hazard Information | Back Directory | [Uses]
GR 89696 free base is a highly selective κ2 opioid receptor agonist with potential to prevent pruritus[1]. | [Definition]
ChEBI: 4-[2-(3,4-dichlorophenyl)-1-oxoethyl]-3-(1-pyrrolidinylmethyl)-1-piperazinecarboxylic acid methyl ester is a member of acetamides. | [in vivo]
GR 89696 free base (intramuscular injection, 0.01-0.1 μg/kg) attenuates the scratching response induced by intrathecal morphine (0.03mg) in a dose-dependent manner without affecting the analgesic effect of morphine[1].
GR-896960 free base (subcutaneous injection, 1 mg/kg) reduces cerebral artery infarct volume by 38% in a rat model of permanent focal ischemia[2].
| [References]
[1] Mei-Chuan Ko, et al. Effects of atypical kappa-opioid receptor agonists on intrathecal morphine-induced itch and analgesia in primates. J Pharmacol Exp Ther. 2009 Jan;328(1):193-200. DOI:10.1124/jpet.108.143925
[2] A Barber, et al. Effects of GR-89696 and the novel peripherally selective OP2 agonists, EMD-61569 and EMD-61747, against focal cerebral ischemia in the rat. Methods Find Exp Clin Pharmacol. 1999 Mar;21(2):105-13 DOI:10.1358/mf.1999.21.2.529237 |
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