| Identification | Back Directory | [Name]
GR 89696 FUMARATE | [CAS]
126766-32-3 | [Synonyms]
GR 89696
GR 89696 FUMARATE
GR 89696 fumarate salt solid
Methyl 4-(2-(3,4-dichlorophenyl)acetyl)-3-(pyrrolidin-1-ylmethyl)piperazine-1-carboxylate fumarate
4-((3,4-Dichlorophenyl)acetyl)-3-(1-pyrrolidinylmethyl)-1-piperazinecarboxylicacidmethylesterfumarate
4-([3,4-DICHLOROPHENYL]ACETYL)-3-(1-PYRROLIDINYLMETHYL)-1-PIPERAZINECARBOXYLIC ACID METHYL ESTER FUMARATE | [Molecular Formula]
C23H29Cl2N3O7 | [MDL Number]
MFCD00274044 | [MOL File]
126766-32-3.mol | [Molecular Weight]
530.4 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at RT | [solubility ]
ethanol: 4.0 mg/mL | [form ]
solid | [color ]
off-white | [InChIKey]
ABTNETSDXZBJTE-WLHGVMLRSA-N | [SMILES]
OC(=O)\C=C\C(O)=O.COC(=O)N1CCN(C(CN2CCCC2)C1)C(=O)Cc3ccc(Cl)c(Cl)c3 |
| Hazard Information | Back Directory | [Uses]
GR 89696 is a selective κ-opioid receptor agonist with anti-nociceptive and neuroprotective properties. | [Biological Activity]
Highly potent and selective κ -opioid agonist (IC 50 = 0.04 nM) that may be selective for the putative κ 2 receptor. Anti-nociceptive and neuroprotective in vivo . | [in vivo]
GR 89696 (intramuscular injection, 0.01-0.1 μg/kg) attenuates the scratching response induced by intrathecal morphine (0.03mg) in a dose-dependent manner without affecting the analgesic effect of morphine[1].
GR-896960(subcutaneous injection, 1 mg/kg) reduces cerebral artery infarct volume by 38% in a rat model of permanent focal ischemia[2].
| [storage]
Store at +4°C |
|
| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|