| Chemical Properties | Back Directory | [Boiling point ]
646.7±55.0 °C(Predicted) | [density ]
1.243±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
11.29±0.70(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
DIPQUO is an activator of the bone marker alkaline phosphatase (ALP), with an EC50 of 6.27 μM in C2C12 cells. DIPQUO promotes mouse and human osteoblast differentiation via activation of p38 MAPK-β[1]. | [Biological Activity]
DIPQUO is a potent activator of the bone marker alkaline phosphatase (ALP) th at promotes osteogenesis in human MSCs and zebrafish. DIPQUO potently induces osteoblast differentiation. It promotes bone formation and regeneration in zebra fish. It appears th at DIPQUO promotes activation of the β isoform of p38 MAP kinase | [storage]
Store at -20°C | [References]
[1] Cook B, et al. Discovery of a Small Molecule Promoting Mouse and Human Osteoblast Differentiation via Activation of p38 MAPK-β. Cell Chem Biol. 2019 Mar 29. DOI:10.1016/j.chembiol.2019.03.009 |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
MedChemExpress
|
| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
|