Identification | Back Directory | [Name]
4H-1-Benzopyran-3-carboxylic acid, 7-chloro-2-(2,5-difluorophenyl)-4-oxo- | [CAS]
1272322-42-5 | [Synonyms]
4H-1-Benzopyran-3-carboxylic acid, 7-chloro-2-(2,5-difluorophenyl)-4-oxo- | [Molecular Formula]
C16H7ClF2O4 | [MOL File]
1272322-42-5.mol | [Molecular Weight]
336.67 |
Chemical Properties | Back Directory | [Boiling point ]
456.2±45.0 °C(Predicted) | [density ]
1.604±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
1.84±0.20(Predicted) | [color ]
White to off-white |
Hazard Information | Back Directory | [Uses]
TNF-α-IN-18 (Compound 61) is an inhibitor for TNF-α (IC50 of 1.8 μM), that inhibits TNF signaling pathway through block of NF-kB migration from cytoplasm to nucleus. TNF-α-IN-18 exhibits slight cytotoxicity to mouse fibroblast LM cell, with a CC50 >50 μM. TNF-α-IN-18 ameliorates the TNF- or Lipopolysaccharide (HY-D1056)-induced sepsis in mouse models. TNF-α-IN-18 protects mice from rheumatoid arthritis[1]. | [References]
[1] Heo T, et al., Composition for preventing or treating tnf-related diseases, containing novel derivative as active ingredient, and method for inhibiting tnf activity by using same. WO2019078452 A1. |
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