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1272322-42-5

1272322-42-5 Structure

1272322-42-5 Structure
IdentificationBack Directory
[Name]

4H-1-Benzopyran-3-carboxylic acid, 7-chloro-2-(2,5-difluorophenyl)-4-oxo-
[CAS]

1272322-42-5
[Synonyms]

4H-1-Benzopyran-3-carboxylic acid, 7-chloro-2-(2,5-difluorophenyl)-4-oxo-
[Molecular Formula]

C16H7ClF2O4
[MOL File]

1272322-42-5.mol
[Molecular Weight]

336.67
Chemical PropertiesBack Directory
[Boiling point ]

456.2±45.0 °C(Predicted)
[density ]

1.604±0.06 g/cm3(Predicted)
[form ]

Solid
[pka]

1.84±0.20(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

TNF-α-IN-18 (Compound 61) is an inhibitor for TNF-α (IC50 of 1.8 μM), that inhibits TNF signaling pathway through block of NF-kB migration from cytoplasm to nucleus. TNF-α-IN-18 exhibits slight cytotoxicity to mouse fibroblast LM cell, with a CC50 >50 μM. TNF-α-IN-18 ameliorates the TNF- or Lipopolysaccharide (HY-D1056)-induced sepsis in mouse models. TNF-α-IN-18 protects mice from rheumatoid arthritis[1].
[References]

[1] Heo T, et al., Composition for preventing or treating tnf-related diseases, containing novel derivative as active ingredient, and method for inhibiting tnf activity by using same. WO2019078452 A1.
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