| Identification | Back Directory | [Name]
Raxofelast | [CAS]
128232-14-4 | [Synonyms]
IRFI-016
Raxofelast
2-(5-acetoxy-4,6,7-trimethyl-2,3-dihydrobenzofuran-2-yl)acetic acid
2-Benzofuranacetic acid, 5-(acetyloxy)-2,3-dihydro-4,6,7-trimethyl- | [Molecular Formula]
C15H18O5 | [MDL Number]
MFCD00866136 | [MOL File]
128232-14-4.mol | [Molecular Weight]
278.302 |
| Hazard Information | Back Directory | [Uses]
Raxofelast (IRFI-016) is an antioxidant agent in various models of ischemia-reperfusion injury. Raxofelast has antiproliferative activity in H2O2-stimulated rat aortic smooth muscle cells. Raxofelast attenuates the activation of mitogen-activating protein kinase (MAPK), ERK kinase 1, 2 (MEK1,2) and protein kinase C (PKC) without affecting Ras expression[1]. | [References]
[1] Kyung-Hye Lee, et al. Antiproliferative mechanisms of raxofelast (IRFI-016) in H2O2-stimulated rat aortic smooth muscle cells. Eur J Pharmacol. 2004, 484, 2-3. DOI:10.1016/j.ejphar.2003.11.012 |
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