| Identification | Back Directory | [Name]
Melarsomine | [CAS]
128470-15-5 | [Synonyms]
Melarsomine
2-N-[4-[bis(2-aminoethylsulfanyl)arsanyl]phenyl]-1,3,5-triazine-2,4,6-triamine
bis(2-aminoethyl)(4-((4,6-diamino-1,3,5-triazin-2-yl)amino)phenyl)arsonodithioite | [Molecular Formula]
C13H21AsN8S2 | [MDL Number]
MFCD00868803 | [MOL File]
128470-15-5.mol | [Molecular Weight]
428.41 |
| Hazard Information | Back Directory | [Uses]
Melarsomine is a trivalent arsenical compound used as an adulticide. Melarsomine can be used for the reserach of canine heartworm disease and other helminth infections[1][2]. | [Veterinary Drugs and Treatments]
Melarsomine is indicated for the treatment of stabilized class I, II,
and III heartworm
disease caused by immature (4 month old, stage
L5) to mature adult infections of D. immitis in dogs. When compared
with thiacetarsamide, melarsomine appears to be more efficacious,
less irritating
to tissues, and does not cause hepatic necrosis.
Melarsomine may also be useful for treating ferrets; it has been
suggested to contact the manufacturer before using the drug in this
species. | [in vivo]
Melarsomine (2.5 mg/kg; deep i.m. injection) combined with Doramectin managed to clear the D. repensinfection in dogs[1].
Melarsomine (0.25 mg/kg; deep i.m. injection) can cure T. evansiinfection in camels[2].
Melarsomine (0.5 mg/kg; deep i.m. injection) can cure T. evansiinfection in dairy cattle in Thailand[2]. | [References]
[1] Baneth G, et, al. Dirofilaria repens infection in a dog: diagnosis and treatment with melarsomine and doramectin. Vet Parasitol. 2002 Apr 30;105(2):173-8. DOI:10.1016/s0304-4017(02)00006-7
[2] Desquesnes M, et, al. An evaluation of melarsomine hydrochloride efficacy for parasitological cure in experimental infection of dairy cattle with Trypanosoma evansi in Thailand. Parasitology. 2011 Aug;138(9):1134-42. DOI:10.1017/S0031182011000771 |
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