| Identification | Back Directory | [Name]
ML167 | [CAS]
1285702-20-6 | [Synonyms]
ML167
CS-1892
NCGC00188654
ML167/ML-167
CID 44968231
ML167 USP/EP/BP
ML167 >=98% (HPLC)
CID44968231;NCGC00188654
ML167; ML-167; ML 167; CID 44968231
5-[4-[[(5-Methyl-2-furanyl)methyl]amino]-6-quinazolinyl]-2-furanmethanol
(5-(4-(((5-Methylfuran-2-yl)methyl)amino)quinazolin-6-yl)furan-2-yl)methanol
5-[4-[[(5-Methyl-2-furanyl)methyl]amino]-6-quinazolinyl]-2-furanmethanol ML167 | [EINECS(EC#)]
808-432-9 | [Molecular Formula]
C19H17N3O3 | [MDL Number]
MFCD27978379 | [MOL File]
1285702-20-6.mol | [Molecular Weight]
335.36 |
| Chemical Properties | Back Directory | [Boiling point ]
531.8±45.0 °C(Predicted) | [density ]
1.335±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: soluble10mg/mL, clear | [form ]
powder | [pka]
13.84±0.10(Predicted) | [color ]
off-white to gray to brown | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. | [InChI]
1S/C19H17N3O3/c1-12-2-4-14(24-12)9-20-19-16-8-13(3-6-17(16)21-11-22-19)18-7-5-15(10-23)25-18/h2-8,11,23H,9-10H2,1H3,(H,20,21,22) | [InChIKey]
ROCFOIBAEVAOLQ-UHFFFAOYSA-N | [SMILES]
N(Cc4[o]c(cc4)C)c1ncnc2c1cc(cc2)c3[o]c(cc3)CO |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
22 | [Safety Statements ]
46 | [WGK Germany ]
3 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral |
| Hazard Information | Back Directory | [Description]
ML167 (1285702-20-6) is a highly selective cell permeable inhibitor of Cdc2-like kinase 4 (Clk4) – IC50?= 136nM. It displays at least 10-fold greater selectivity over the related kinases Clk1(1.52 μM), Clk2(1.65μM), Clk3(>10μM), Dyrk1A(>10μM), and Dyrk1B(4.4 μM). | [Uses]
ML167 is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor with IC50 of 136 nM, >10-fold selectivity for closely related kinases Clk1, Clk2, Clk3 and Dyrk1A/1B[1]. | [Definition]
ChEBI: [5-[4-[(5-methyl-2-furanyl)methylamino]-6-quinazolinyl]-2-furanyl]methanol is a member of quinazolines. | [target]
Clk4 | [IC 50]
CLK4: 136 nM (IC50); CLK1: 1522 nM (IC50); CLK2: 1648 nM (IC50); DYRK1B: 4420 nM (IC50); CDK3: ＞10000 nM (IC50); DYRK1A: ＞10000 nM (IC50) | [References]
1) Rosenthal?et al. (2010),?An inhibitor of the Cdc2-like kinase 4 (Clk4); Probe Reports from the NIH Molecular Libraries Program |
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