| Identification | Back Directory | [Name]
Di-O-acetylbritannilactone | [CAS]
1286694-67-4 | [Synonyms]
Britannilactone diacetate
Di-O-acetylbritannilactone
(3aR,4S,7aR)-4-(Acetyloxy)-5-[(1S)-4-(acetyloxy)-1-methylbutyl]-3a,4,7,7a-tetrahydro-6-methyl-3-methylene-2(3H)-benzofuranone
2(3H)-Benzofuranone, 4-(acetyloxy)-5-[(1S)-4-(acetyloxy)-1-methylbutyl]-3a,4,7,7a-tetrahydro-6-methyl-3-methylene-, (3aR,4S,7aR)- | [Molecular Formula]
C19H26O6 | [MOL File]
1286694-67-4.mol | [Molecular Weight]
350.41 |
| Hazard Information | Back Directory | [Uses]
Britannilactone diacetate (1,6-O,O-Diacetylbritannilactone; Compound 2) exhibits potential NO inhibition effect. Britannilactone diacetate exhibits activity against NO production induced by?LPS?in BV-2 microglial cells with the EC50?value of 6.3?μM.?Britannilactone diacetate exhibits a favorable blood-brain barriers (BBB) penetration and absorption, distribution, metabolism, excretion, and toxicity (ADMET) property[1]. | [References]
[1] Tang JJ, et al. 1,10-Seco-Eudesmane sesquiterpenoids as a new type of anti-neuroinflammatory agents by suppressing TLR4/NF-κB/MAPK pathways. Eur J Med Chem. 2021 Nov 15;224:113713. DOI:10.1016/j.ejmech.2021.113713 |
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