| Identification | Back Directory | [Name]
Carbamic acid, N-[(1S,2S)-1-[[(3S)-3,4-dihydro-7-[2-(hydroxyamino)-2-oxoethoxy]-3-[[(4-methoxyphenyl)amino]carbonyl]-2(1H)-isoquinolinyl]carbonyl]-2-methylbutyl]-, 1,1-dimethylethyl ester | [CAS]
1287261-04-4 | [Synonyms]
ZYJ25e
ZYJ-25e
ZYJ 25e
Carbamic acid, N-[(1S,2S)-1-[[(3S)-3,4-dihydro-7-[2-(hydroxyamino)-2-oxoethoxy]-3-[[(4-methoxyphenyl)amino]carbonyl]-2(1H)-isoquinolinyl]carbonyl]-2-methylbutyl]-, 1,1-dimethylethyl ester | [Molecular Formula]
C30H40N4O8 | [MOL File]
1287261-04-4.mol | [Molecular Weight]
584.66 |
| Hazard Information | Back Directory | [Description]
ZYJ-25e is a histone deacetylase inhibitor (HDACi) with potent oral antitumor activities. | [Uses]
ZYJ-25e is a potent histone deacetylase inhibitor (HDACi) with IC50s of 0.047 μM and 0.139 μM for HDAC6 and HDAC8, respectively. ZYJ-25e is a tetrahydroisoquinoline-bearing hydroxamic acid analogue. ZYJ-25e shows marked antitumor potency in the MDA-MB231 xenograft model[1]. | [IC 50]
HDAC6: 0.047 μM (IC50); HDAC8: 0.139 μM (IC50) | [References]
[1] Yingjie Zhang, et al. Discovery of a tetrahydroisoquinoline-based hydroxamic acid derivative (ZYJ-34c) as histone deacetylase inhibitor with potent oral antitumor activities. J Med Chem. 2011 Aug 11;54(15):5532-9. DOI:10.1021/jm200577a |
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