| Identification | Back Directory | [Name]
KRIBB 3 | [CAS]
129414-88-6 | [Synonyms]
4-Ethyl-5-methoxy-2-[4-(4-methoxyphenyl)-5-isoxazolyl]phenol
Phenol, 4-ethyl-5-methoxy-2-[4-(4-methoxyphenyl)-5-isoxazolyl]-
KRIBB3 (5-(5-Ethyl-2-hydroxy-4-methoxyphenyl)-4-(4-methoxyphenyl)isoxazole)
4-ethyl-3-methoxy-6-[4-(4-methoxyphenyl)-2H-isoxazol-5-ylidene]-1-cyclohexa-2,4-dienone | [Molecular Formula]
C19H19NO4 | [MDL Number]
MFCD00710140 | [MOL File]
129414-88-6.mol | [Molecular Weight]
325.36 |
| Chemical Properties | Back Directory | [Melting point ]
147-148 °C | [Boiling point ]
467.5±45.0 °C(Predicted) | [density ]
1.181±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C | [solubility ]
DMSO: 25 mM | [form ]
A solid | [pka]
8.51±0.48(Predicted) |
| Hazard Information | Back Directory | [Uses]
Kribb3 is an inhibitor for microtubule. KRIBB3 inhibits the proliferation of cancer cells with GI50 of 0.2-2.5 μM, arrests cell cycle at G2/M phase, and induces apoptosis in HCT-116. Kribb3 exhibits antitumor activity in mouse models[1]. | [References]
[1] Shin KD, et al., KRIBB3, a novel microtubule inhibitor, induces mitotic arrest and apoptosis in human cancer cells. Biochem Pharmacol. 2008 Jan 15;75(2):383-94. DOI:10.1016/j.bcp.2007.08.027 |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Biorbyt Ltd.
|
| Tel: |
+44 (0)1223 859 353 |
| Website: |
http://www.biorbyt.com |
| Company Name: |
Abcam Limited
|
| Tel: |
021-2070050 400921018 |
| Website: |
www.abcam.cn |
|