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His-Gly-Asp-Gly-Ser-Phe-Ser-Asp-Glu-{Nle}-{d-Phe}-Thr-Ile-Leu-Asp-Leu-Leu-Ala-Ala-Arg-Asp-Phe-Ile-Asn-Trp-Leu-Ile-Gln-Thr-Lys-Ile-Thr-Asp-NH2 |
| Hazard Information | Back Directory | [Uses]
Apraglutide (FE 203799), a synthetic 33-amino-acid peptide and a long-acting GLP-2 analogue, enhances adaptation and linear intestinal growth in a neonatal piglet model of short bowel syndrome with total resection of the ileum[1]. | [in vivo]
Apraglutide (FE 203799; 5 mg/kg/dose, subcutaneously, twice on days 0 and 4 postsurgery) treated piglets are healthy, have significant lower fecal fat and energy losses and exhibite intestinal lengthening, greater small-intestinal weight, longer villus height, and greater crypt depth on day 7[1].
| Animal Model: | NewbornDuroc piglets, 2–5 days old and weighing between 2-2.6 kg[1]. | | Dosage: | 5 mg/kg/dose. | | Administration: | Subcutaneously, twice on days 0 and 4 postsurgery. | | Result: | On day 7, treated piglets were healthy, had significant lower fecal fat and energy losses and exhibited intestinal lengthening, greater small-intestinal weight, longer villus height, and greater crypt depth. |
| [References]
[1] Slim GM, et al. Novel Long-Acting GLP-2 Analogue, FE 203799 (Apraglutide), Enhances Adaptation and Linear Intestinal Growth in a Neonatal Piglet Model of Short Bowel Syndrome with Total Resection of the Ileum. JPEN J Parenter Enteral Nutr. 2019 Jan 6. DOI:10.1002/jpen.1500 |
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