| Identification | Back Directory | [Name]
8-(4-CHLOROPHENYLTHIO)ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT | [CAS]
129735-01-9 | [Synonyms]
RP-8-CPT-CAMPS
RP-8-CPT-CAMPS SODIUM SALT
8-(4-CHLOROPHENYLTHIO)ADENOSINE-*3',5-CYCLIC MONOPH
8-(4-CHLOROPHENYLTHIO)ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER
Adenosine, 8-[(4-chlorophenyl)thio]-, cyclic 3',5'-[hydrogen [P(R)]-phosphorothioate]
8-(4-CHLOROPHENYLTHIO)ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT
8-(4-chlorophenylthio)adenosine-3’,5’-cyclicmonophosphorothioate,spisomer(sp-8-cpt-camps),sodi | [Molecular Formula]
C16H15ClN5O5PS2 | [MDL Number]
MFCD04113744 | [MOL File]
129735-01-9.mol | [Molecular Weight]
487.88 |
| Chemical Properties | Back Directory | [storage temp. ]
−20°C
| [form ]
solid
| [biological source]
synthetic (organic) | [InChIKey]
AWXMSJRRXLCVMW-JVSRKQJHSA-M | [SMILES]
[Na+].Nc1ncnc2n([C@@H]3O[C@@H]4COP([S-])(=O)O[C@H]4[C@H]3O)c(Sc5ccc(Cl)cc5)nc12 |
| Hazard Information | Back Directory | [Uses]
Rp-8-CPT-cAMPS, a cAMP analog, is a potent and competitive antagonist of cAMP-induced activation of cAMP-dependent PKA I and II. Rp-8-CPT-cAMPS preferentially selects site A of RI compares to site A of RII and site B of RII compares to site B of RI[1][2]. | [Biological Activity]
Lipophilic analog of the competitive inhibitor of protein kinase A (cyclic AMP antagonist). | [References]
[1] Dostmann WR , et, al. Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates. J Biol Chem. 1990 Jun 25;265(18):10484-91. PMID:2162349
[2] Roscioni SS, et, al. PKA and Epac cooperate to augment bradykinin-induced interleukin-8 release from human airway smooth muscle cells. Respir Res. 2009 Sep 29;10(1):88. DOI:10.1186/1465-9921-10-88
[3] Chaisakul J, et, al. In vivo and in vitro cardiovascular effects of Papuan taipan (Oxyuranus scutellatus) venom: Exploring "sudden collapse". Toxicol Lett. 2012 Sep 3;213(2):243-8. DOI:10.1016/j.toxlet.2012.06.015 |
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