| Identification | Back Directory | [Name]
2,4-Dichloro-5-methyl-5H-pyrrolo[3,2-d]pyrimidine | [CAS]
129872-81-7 | [Synonyms]
2,4-Dichloro-5-methyl-5H-pyrrolo[3,2-d]pyrimidine
5H-Pyrrolo[3,2-d]pyrimidine,2,4-dichloro-5-methyl- | [Molecular Formula]
C7H5Cl2N3 | [MDL Number]
MFCD12755925 | [MOL File]
129872-81-7.mol | [Molecular Weight]
202.044 |
| Hazard Information | Back Directory | [Synthesis]
1. 2,4-Dichloro-5H-pyrrolo[3,2-d]pyrimidine (600 mg, 3.19 mmol) and N,N-dimethylformamide (DMF, 5 mL) were added to a round-bottomed flask and stirred until completely dissolved.
2. Add iodomethane (544 mg, 3.83 mmol) and cesium carbonate (520 mg, 1.60 mmol) to the reaction system sequentially.
3. Stir the reaction for 24 hours at room temperature. 4.
4. After completion of the reaction, the reaction solution was poured into water and extracted with ethyl acetate.
5. The organic phases were combined, dried over anhydrous sodium sulfate, filtered and concentrated to give a yellow solid product.
6. Yield: 91%. | [References]
[1] Patent: CN107312006, 2017, A. Location in patent: Paragraph 0037-0039
[2] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 15, p. 3486 - 3492
[3] Patent: CN104177363, 2018, B. Location in patent: Paragraph 0247; 0250-0251
[4] Patent: WO2015/193168, A1. Location in patent: Page/Page column 59
[4] Patent: , 2015, . Location in patent: Page/Page column 59 |
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