| Identification | Back Directory | [Name]
THIFLUZAMIDE | [CAS]
130000-40-7 | [Synonyms]
Pulsor
Greatam
Granual
MON 2400
mon24000
RH 130753
trifuzamide
THIFLUZAMIDE
Thifluzamide [iso]
THIFLUZAMIDE STANDARD
Cooling taste agent ws-3
thifluzamide (bsi,iso,ansi)
Thiuzamide, 10 μg /μL in acetonitrile
2'，6'-diobromo-2-methyl-4'-trifluoromethyox-4-trifluoromethyl-1,3-thiazole-5-carboxanilide
N-(2,6-Dibromo-4-(trifluoromethoxy)phenyl)-2-methyl-4-(trifluoromethyl)thiazole-5-carboxamide
5-Thiazolecarboxamide, N-(2,6-dibromo-4-(trifluoromethoxy)phenyl)-2-methyl-4-(trifluoromethyl)- | [EINECS(EC#)]
1592732-453-0 | [Molecular Formula]
C13H6Br2F6N2O2S | [MDL Number]
MFCD03428071 | [MOL File]
130000-40-7.mol | [Molecular Weight]
528.06 |
| Chemical Properties | Back Directory | [Melting point ]
178℃ | [Boiling point ]
375.9±42.0 °C(Predicted) | [density ]
1.930 | [storage temp. ]
0-6°C | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
neat | [pka]
8.24±0.70(Predicted) | [color ]
White to Gray to Red | [Henry's Law Constant]
1.2×106 mol/(m3Pa) at 25℃, Ebert et al. (2023) | [Major Application]
agriculture
environmental | [InChI]
InChI=1S/C13H6Br2F6N2O2S/c1-4-22-10(12(16,17)18)9(26-4)11(24)23-8-6(14)2-5(3-7(8)15)25-13(19,20)21/h2-3H,1H3,(H,23,24) | [InChIKey]
WOSNCVAPUOFXEH-UHFFFAOYSA-N | [SMILES]
S1C(C(NC2=C(Br)C=C(OC(F)(F)F)C=C2Br)=O)=C(C(F)(F)F)N=C1C | [CAS DataBase Reference]
130000-40-7 | [EPA Substance Registry System]
5-Thiazolecarboxamide, N-[2,6-dibromo-4-(trifluoromethoxy)phenyl]-2-methyl-4-(trifluoromethyl)- (130000-40-7) |
| Hazard Information | Back Directory | [Definition]
ChEBI: An aromatic amide obtained by formal condensation of the carboxy group of 2-methyl-4-(trifluoromethyl)thiazole-5-carboxylic acid with the amino group of 2,6-dibromo-4-(trifluoromethoxy)aniline. Used to control Rhizoctonia spp. diseases on rice
potatoes, maize, grass and other crops. | [Chemical Properties]
The pure product is a white powdery solid with mp of 177.9-178.6℃, a solubility of 1.6 mg/L in water at 20℃, a distribution coefficient of 4.1, and is stable at pH 5-9. | [Uses]
Thifluzamide is a fungicide found in cereals, vegetables and fruits; A succinate dehydrogenase inhibitor. | [Production Methods]
The industrial production of thifluzamide begins with the preparation of a substituted aniline derivative, which undergoes selective bromination and trifluoromethoxylation to form a highly halogenated aromatic intermediate. This is then coupled with a thiazolecarboxylic acid derivative via amide bond formation, yielding the final compound. | [Mechanism of action]
Systemic, absorbed by roots and translocated, inhibits succinate dehydrogenase in the tricarboxylic acid cycle | [storage]
Store at -20°C | [Pesticide Type]
Fungicide |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS09 | [Signal word ]
Warning | [Hazard statements ]
H410 | [Precautionary statements ]
P273-P391-P501 | [Hazard Codes ]
N | [Risk Statements ]
50/53 | [Safety Statements ]
60-61 | [RIDADR ]
UN 3077 9 / PGIII | [WGK Germany ]
3 | [HazardClass ]
9 | [PackingGroup ]
III | [HS Code ]
29341000 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Aquatic Acute 1
Aquatic Chronic 1 |
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Jia Xing Isenchem Co.,Ltd
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