| Identification | Back Directory | [Name]
2-chloro-7,8-dihydro-6H-pyrimido[5,4-b][1,4]oxazine | [CAS]
1303587-99-6 | [Synonyms]
2-chloro-7,8-dihydro-6H-pyrimido[5,4-b][1,4]oxazine | [Molecular Formula]
C6H6ClN3O | [MDL Number]
MFCD20688597 | [MOL File]
1303587-99-6.mol | [Molecular Weight]
171.58 |
| Chemical Properties | Back Directory | [Boiling point ]
391.3±31.0 °C(Predicted) | [density ]
1.409±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [pka]
3.11±0.20(Predicted) |
| Hazard Information | Back Directory | [Synthesis]
To 4-amino-2-chloropyrimidin-5-ol (67; 3.75 g, 25.8 mmol) and 1,2-dibromoethane (4.85 g, 25.8 mmol) was added potassium carbonate (10.68 g, 77.4 mmol) in dichloromethane (2500 mL). The reaction mixture was heated to reflux for 4 hours. Upon completion of the reaction, the insoluble solids were removed by filtration. The filtrate was concentrated and the resulting residue was purified by column chromatography to afford the target compound 2-chloro-7,8-dihydro-6H-pyrimido[5,4-b][1,4]oxazine (68; 3.18 g, 72% yield). Mass spectrometry (ESI) analysis: calculated value (C6H6ClN3O): 171.58; measured value: 173 [M + H]. | [References]
[1] Patent: WO2011/59839, 2011, A1. Location in patent: Page/Page column 92 |
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AstaTech, Inc
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