| Identification | Back Directory | [Name]
DL-AP5 sodium salt | [CAS]
1303993-72-7 | [Synonyms]
DL-AP5.Na
DL-AP5 sodium salt
2-AMINO-5-PHOSPHOVALERIC ACID SODIUM SALT
DL-2-Amino-5-phosphonopentanoicacidsodiumsalt
DL-AP-5 Sodium salt,DL AP5 Sodium salt,DLAP5 Sodium salt | [Molecular Formula]
C5H11NNaO5P | [MDL Number]
MFCD12195844 | [MOL File]
1303993-72-7.mol | [Molecular Weight]
221.12 |
| Chemical Properties | Back Directory | [Melting point ]
>142oC (dec.) | [storage temp. ]
Store at RT | [solubility ]
Aqueous Acid (Slightly, Sonicated), Aqueous Base (Slightly), Water (Slightly) | [form ]
Solid | [color ]
White to Off-White | [Water Solubility ]
Soluble to 100 mM in water | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Uses]
DL-AP5 is a potent NMDA antagonist (1). | [in vivo]
DL-AP5 (0-10 μg/rat, Intra-CA1) significantly decreases the effect of NMDA[3].
DL-AP5 (0-10 nmol, Intracerebroventricular injection) causes a dose-dependent increase in food consumption[4].
DL-AP5 (5 nmol, Intracerebroventricular injection) attenuates the decreased food consumption induced by the intracerebroventricular injection of ghrelin[4]. | Animal Model: | Male Wistar rats (180-230 g)[3] | | Dosage: | 1, 3.2 and 10 μg/rat | | Administration: | Injected into the intra-dorsal hippocampal (intra-CA1) immediately after shock administration, once | | Result: | Significantly decreased the effect of NMDA (10-2 μg/rat, intra-CA1) with significant interaction. |
| Animal Model: | Broilers cockerels (3-h fooddeprived (FD3), n=8 for each group)[4] | | Dosage: | 0, 2.5, 5, and 10 nmol; in a volume of 10 μL | | Administration: | Intracerebroventricular injection | | Result: | Caused a dose-dependent increase in food consumption which was significant for 5 and 10 nmol doses. |
| Animal Model: | Broilers cockerels (3-h fooddeprived (FD3), n=8 for each group)[4] | | Dosage: | 5 nmol | | Administration: | Intracerebroventricular injection, followed by ghrelin (0.6 nmol) | | Result: | Attenuated the decreased food consumption induced by the intracerebroventricular injection of ghrelin. |
| [IC 50]
NMDA Receptor | [storage]
Room temperature (desiccate) |
|
| Company Name: |
BOC Sciences
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https://www.bocsci.com |
| Company Name: |
Energy Chemical
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021-58432009 400-005-6266 |
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http://www.energy-chemical.com |
| Company Name: |
Wuhan Topule
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+86-02787215551 +86-19945035818 |
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http://www.topule.com/ |
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